Reactome | ERCC3-facilitated RNA Pol II backtracking in TC-NER

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ERCC3-facilitated RNA Pol II backtracking in TC-NER Show undefined attributes

authored	[InstanceEdit:6782121] Orlic-Milacic, Marija, 2015-06-04
catalystActivity	[CatalystActivity:9684122] 3'-5' DNA helicase activity of TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9684116] Orlic-Milacic, Marija, 2020-04-20
dbId	9684118
displayName	ERCC3-facilitated RNA Pol II backtracking in TC-NER
edited	[InstanceEdit:9689740] Orlic-Milacic, Marija, 2020-05-21
eventOf	[Pathway:R-HSA-6782135] Dual incision in TC-NER - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-9684117] TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6782132] Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome [LiteratureReference:6782126] UvrD facilitates DNA repair by pulling RNA polymerase backwards [LiteratureReference:5689311] Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair [LiteratureReference:5689302] Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation [LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ERCC3-facilitated RNA Pol II backtracking in TC-NER
orthologousEvent	[Reaction:R-MMU-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Mus musculus [Reaction:R-PFA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Plasmodium falciparum [Reaction:R-SCE-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Saccharomyces cerevisiae [Reaction:R-SPO-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Schizosaccharomyces pombe [Reaction:R-DDI-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Dictyostelium discoideum [Reaction:R-CEL-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Caenorhabditis elegans [Reaction:R-DME-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Drosophila melanogaster [Reaction:R-GGA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Gallus gallus [Reaction:R-XTR-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Xenopus tropicalis [Reaction:R-DRE-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Danio rerio [Reaction:R-SSC-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Sus scrofa [Reaction:R-BTA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Bos taurus [Reaction:R-CFA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Canis familiaris [Reaction:R-RNO-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-6782111] TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03 [InstanceEdit:9684094] D'Eustachio, Peter, 2020-04-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9684118
summation	[Summation:9684115] The DNA helicase XPB (ERCC3), which is part of the TFIIH com...

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(hasEvent)

[Pathway:R-HSA-6782135] Dual incision in TC-NER

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