Reactome | Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER

Schema > Reaction > Entries

Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER Show undefined attributes

authored	[InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782143] Orlic-Milacic, Marija, 2015-06-04
dbId	6782141
displayName	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-6782135] Dual incision in TC-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER - Homo sapiens
input	[Complex:R-HSA-109943] ERCC1:ERCC4 [nucleoplasm] [Complex:R-HSA-6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5689261] The comings and goings of nucleotide excision repair factors on damaged DNA [LiteratureReference:5689616] Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA [LiteratureReference:5689611] The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
orthologousEvent	[Reaction:R-MMU-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Mus musculus [Reaction:R-SPO-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Schizosaccharomyces pombe [Reaction:R-DDI-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Dictyostelium discoideum [Reaction:R-CEL-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Caenorhabditis elegans [Reaction:R-DME-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Drosophila melanogaster [Reaction:R-DRE-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Danio rerio [Reaction:R-SSC-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Sus scrofa [Reaction:R-BTA-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Bos taurus [Reaction:R-CFA-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Canis familiaris [Reaction:R-RNO-6782141] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER - Rattus norvegicus
output	[Complex:R-HSA-6782142] TC-NER incision complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782141
summation	[Summation:6782140] ERCC1:ERCC4 (ERCC1:XPF) DNA endonuclease complex binds to th...

Referrals

(hasEvent)	[Pathway:R-HSA-6782135] Dual incision in TC-NER
(precedingEvent)	[Reaction:R-HSA-6782204] 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER