Reactome | ERCC2-facilitated RNA Pol II backtracking in TC-NER

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ERCC2-facilitated RNA Pol II backtracking in TC-NER Show undefined attributes

authored	[InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
catalystActivity	[CatalystActivity:6782120] 5'-3' DNA helicase activity of TC-NER pre-incision complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6782121] Orlic-Milacic, Marija, 2015-06-04
dbId	6782131
deleted	[Deleted:6793202] Deletion of instance: 109974
displayName	ERCC2-facilitated RNA Pol II backtracking in TC-NER
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-6782135] Dual incision in TC-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site - Homo sapiens [Reaction:R-HSA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-6782066] TC-NER pre-incision complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6782132] Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome [LiteratureReference:6782126] UvrD facilitates DNA repair by pulling RNA polymerase backwards [LiteratureReference:5689311] Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair [LiteratureReference:5689302] Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation [LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ERCC2-facilitated RNA Pol II backtracking in TC-NER
orthologousEvent	[Reaction:R-MMU-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Mus musculus [Reaction:R-PFA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Plasmodium falciparum [Reaction:R-SCE-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Saccharomyces cerevisiae [Reaction:R-SPO-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Schizosaccharomyces pombe [Reaction:R-DDI-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Dictyostelium discoideum [Reaction:R-CEL-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Caenorhabditis elegans [Reaction:R-DME-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Drosophila melanogaster [Reaction:R-GGA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Gallus gallus [Reaction:R-XTR-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Xenopus tropicalis [Reaction:R-DRE-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Danio rerio [Reaction:R-SSC-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Sus scrofa [Reaction:R-BTA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Bos taurus [Reaction:R-CFA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Canis familiaris [Reaction:R-RNO-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-HSA-9684117] TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03 [InstanceEdit:9684094] D'Eustachio, Peter, 2020-04-20
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:9684048] Orlic-Milacic, Marija, 2020-04-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6782131
summation	[Summation:6782118] The DNA helicase XPD (ERCC2), which is part of the TFIIH com...
updateTrackers	[UpdateTracker:9777032] Update Tracker - [Reaction:6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - v73:[add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777032] Update Tracker - [Reaction:6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - v73:[add_removeOutput, modifyText]
(replacementInstances)	[Deleted:6793202] Deletion of instance: 109974
(hasEvent)	[Pathway:R-HSA-6782135] Dual incision in TC-NER
(precedingEvent)	[Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site [Reaction:R-HSA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER

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