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Entries
Formation of TC-NER Pre-Incision Complex
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authored
[InstanceEdit:110546] Gopinathrao, G, 2004-02-02 17:30:34
[InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33
[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:6781825] Orlic-Milacic, Marija, 2015-06-02
dbId
6781823
displayName
Formation of TC-NER Pre-Incision Complex
edited
[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
[InstanceEdit:9862096] Orlic-Milacic, Marija, 2024-02-22
eventOf
[Pathway:R-HSA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER) - Homo sapiens
followingEvent
[Pathway:R-HSA-6782135] Dual incision in TC-NER - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-6781818] RNA Pol II initiates transcription from damaged DNA template - Homo sapiens
[BlackBoxEvent:R-HSA-6781824] Active RNA Pol II complex transcribes lesion-containing DNA template - Homo sapiens
[Reaction:R-HSA-6781840] ERCC6 binds stalled RNA Pol II - Homo sapiens
[Reaction:R-HSA-6781833] ERCC8 (CSA) binds stalled RNA Pol II - Homo sapiens
[Reaction:R-HSA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Homo sapiens
[Reaction:R-HSA-6782004] Assembly of the pre-incision complex in TC-NER - Homo sapiens
[Reaction:R-HSA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6782079] CPD damage recognition by transcribing RNA polymerase II
[LiteratureReference:6781862] UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells
[LiteratureReference:6781864] CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome
[LiteratureReference:6782041] Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells
[LiteratureReference:5689269] Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin
[LiteratureReference:6781991] XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription
[LiteratureReference:6781996] Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
[LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
[LiteratureReference:6782011] Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin
[LiteratureReference:6781971] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair
[LiteratureReference:6781993] UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair
[LiteratureReference:6782030] KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)
[LiteratureReference:9862017] Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
Formation of TC-NER Pre-Incision Complex
orthologousEvent
[Pathway:R-PFA-6781823] Formation of TC-NER Pre-Incision Complex - Plasmodium falciparum
[Pathway:R-SCE-6781823] Formation of TC-NER Pre-Incision Complex - Saccharomyces cerevisiae
[Pathway:R-SPO-6781823] Formation of TC-NER Pre-Incision Complex - Schizosaccharomyces pombe
[Pathway:R-DDI-6781823] Formation of TC-NER Pre-Incision Complex - Dictyostelium discoideum
[Pathway:R-CEL-6781823] Formation of TC-NER Pre-Incision Complex - Caenorhabditis elegans
[Pathway:R-DME-6781823] Formation of TC-NER Pre-Incision Complex - Drosophila melanogaster
[Pathway:R-GGA-6781823] Formation of TC-NER Pre-Incision Complex - Gallus gallus
[Pathway:R-XTR-6781823] Formation of TC-NER Pre-Incision Complex - Xenopus tropicalis
[Pathway:R-DRE-6781823] Formation of TC-NER Pre-Incision Complex - Danio rerio
[Pathway:R-SSC-6781823] Formation of TC-NER Pre-Incision Complex - Sus scrofa
[Pathway:R-BTA-6781823] Formation of TC-NER Pre-Incision Complex - Bos taurus
[Pathway:R-CFA-6781823] Formation of TC-NER Pre-Incision Complex - Canis familiaris
[Pathway:R-RNO-6781823] Formation of TC-NER Pre-Incision Complex - Rattus norvegicus
[Pathway:R-MMU-6781823] Formation of TC-NER Pre-Incision Complex - Mus musculus
releaseDate
2004-03-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised
[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6781823
summation
[Summation:6782756] Formation of TC-NER pre-incision complex is initiated when t...
Referrals
(hasEvent)
[Pathway:R-HSA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER)
(precedingEvent)
[Pathway:R-HSA-6782135] Dual incision in TC-NER
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