Reactome | Formation of TC-NER Pre-Incision Complex

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Formation of TC-NER Pre-Incision Complex Show undefined attributes

authored	[InstanceEdit:110546] Gopinathrao, G, 2004-02-02 17:30:34 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6781825] Orlic-Milacic, Marija, 2015-06-02
dbId	6781823
deleted	[Deleted:6793374] Deletion of instance: 110302
displayName	Formation of TC-NER Pre-Incision Complex
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16 [InstanceEdit:9862096] Orlic-Milacic, Marija, 2024-02-22
eventOf	[Pathway:R-HSA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER) - Homo sapiens
followingEvent	[Pathway:R-HSA-6782135] Dual incision in TC-NER - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-6781818] RNA Pol II initiates transcription from damaged DNA template - Homo sapiens [BlackBoxEvent:R-HSA-6781824] Active RNA Pol II complex transcribes lesion-containing DNA template - Homo sapiens [Reaction:R-HSA-6781840] ERCC6 binds stalled RNA Pol II - Homo sapiens [Reaction:R-HSA-6781833] ERCC8 (CSA) binds stalled RNA Pol II - Homo sapiens [Reaction:R-HSA-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Homo sapiens [Reaction:R-HSA-6782004] Assembly of the pre-incision complex in TC-NER - Homo sapiens [Reaction:R-HSA-6782069] UVSSA:USP7 deubiquitinates ERCC6 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-06-27
literatureReference	[LiteratureReference:6782079] CPD damage recognition by transcribing RNA polymerase II [LiteratureReference:6781862] UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells [LiteratureReference:6781864] CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome [LiteratureReference:6782041] Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells [LiteratureReference:5689269] Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin [LiteratureReference:6781991] XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription [LiteratureReference:6781996] Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability [LiteratureReference:6781982] Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template [LiteratureReference:6782011] Chromosomal protein HMGN1 enhances the rate of DNA repair in chromatin [LiteratureReference:6781971] Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair [LiteratureReference:6781993] UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair [LiteratureReference:6782030] KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR) [LiteratureReference:9862017] Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of TC-NER Pre-Incision Complex
orthologousEvent	[Pathway:R-RNO-6781823] Formation of TC-NER Pre-Incision Complex - Rattus norvegicus [Pathway:R-CFA-6781823] Formation of TC-NER Pre-Incision Complex - Canis familiaris [Pathway:R-BTA-6781823] Formation of TC-NER Pre-Incision Complex - Bos taurus [Pathway:R-SSC-6781823] Formation of TC-NER Pre-Incision Complex - Sus scrofa [Pathway:R-DRE-6781823] Formation of TC-NER Pre-Incision Complex - Danio rerio [Pathway:R-XTR-6781823] Formation of TC-NER Pre-Incision Complex - Xenopus tropicalis [Pathway:R-GGA-6781823] Formation of TC-NER Pre-Incision Complex - Gallus gallus [Pathway:R-DME-6781823] Formation of TC-NER Pre-Incision Complex - Drosophila melanogaster [Pathway:R-CEL-6781823] Formation of TC-NER Pre-Incision Complex - Caenorhabditis elegans [Pathway:R-DDI-6781823] Formation of TC-NER Pre-Incision Complex - Dictyostelium discoideum [Pathway:R-SPO-6781823] Formation of TC-NER Pre-Incision Complex - Schizosaccharomyces pombe [Pathway:R-SCE-6781823] Formation of TC-NER Pre-Incision Complex - Saccharomyces cerevisiae [Pathway:R-PFA-6781823] Formation of TC-NER Pre-Incision Complex - Plasmodium falciparum [Pathway:R-MMU-6781823] Formation of TC-NER Pre-Incision Complex - Mus musculus
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6781823
summation	[Summation:6782756] Formation of TC-NER pre-incision complex is initiated when t...
updateTrackers	[UpdateTracker:9783292] Update Tracker - [Pathway:6781823] Formation of TC-NER Pre-Incision Complex - v57:[updateContainedRLE] [UpdateTracker:9864185] Update Tracker - [Pathway:6781823] Formation of TC-NER Pre-Incision Complex - v88:[add_removeLiteratureReference, modifyText, updateContainedRLE]

Referrals

(precedingEvent)	[Pathway:R-HSA-6782135] Dual incision in TC-NER
(hasEvent)	[Pathway:R-HSA-6781827] Transcription-Coupled Nucleotide Excision Repair (TC-NER)
(replacementInstances)	[Deleted:6793374] Deletion of instance: 110302
(updatedInstance)	[UpdateTracker:9783292] Update Tracker - [Pathway:6781823] Formation of TC-NER Pre-Incision Complex - v57:[updateContainedRLE] [UpdateTracker:9864185] Update Tracker - [Pathway:6781823] Formation of TC-NER Pre-Incision Complex - v88:[add_removeLiteratureReference, modifyText, updateContainedRLE]

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