Reactome | MAP2K homo/heterodimers [cytosol]

Schema > DefinedSet > Entries

MAP2K homo/heterodimers [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9656179] activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] - Homo sapiens [Complex:R-HSA-6802695] p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex - Homo sapiens [Reaction:R-HSA-6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Homo sapiens [Reaction:R-HSA-6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Homo sapiens [Reaction:R-HSA-6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs - Homo sapiens [Reaction:R-HSA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Homo sapiens
created	[InstanceEdit:5672719] Rothfels, Karen, 2015-02-05
dbId	5672716
displayName	MAP2K homo/heterodimers [cytosol]
hasMember	[Complex:R-HSA-5672683] MAP2K1 dimer [cytosol] - Homo sapiens [Complex:R-HSA-5672686] MAP2K1:MAPK2K2 heterodimer [cytosol] - Homo sapiens [Complex:R-HSA-5672685] MAP2K2 dimer [cytosol] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-5672716] MAP2K homo/heterodimers [cytosol] - Mus musculus [DefinedSet:R-RNO-5672716] MAP2K homo/heterodimers [cytosol] - Rattus norvegicus [Complex:R-CFA-5672685] MAP2K2 dimer [cytosol] - Canis familiaris [Complex:R-BTA-5672683] MAP2K1 dimer [cytosol] - Bos taurus [Complex:R-SSC-5672685] MAP2K2 dimer [cytosol] - Sus scrofa [DefinedSet:R-DRE-5672716] MAP2K homo/heterodimers [cytosol] - Danio rerio [GenomeEncodedEntity:R-GGA-5672716] Ghost homologue of MAP2K homo/heterodimers [cytosol] - Gallus gallus [DefinedSet:R-DME-5672716] MAP2K homo/heterodimers [cytosol] - Drosophila melanogaster [DefinedSet:R-CEL-5672716] MAP2K homo/heterodimers [cytosol] - Caenorhabditis elegans [DefinedSet:R-DDI-5672716] MAP2K homo/heterodimers [cytosol] - Dictyostelium discoideum
maxDepth	3
name	MAP2K homo/heterodimers
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-5672716

Referrals

(input)	[Reaction:R-HSA-6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs [Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex [Reaction:R-HSA-6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs [Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs [Reaction:R-HSA-6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs [Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs [Reaction:R-HSA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components [Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome [Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
(hasComponent)	[Complex:R-HSA-6802695] p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] [Complex:R-HSA-9656179] activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] [Complex:R-HSA-6802636] RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802645] RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] [Complex:R-HSA-6802667] mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] [Complex:R-HSA-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] [Complex:R-HSA-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] [Complex:R-HSA-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
(activeUnit)	[CatalystActivity:9610157] protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]

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