Reactome | MAP2K1 dimer [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-BTA-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] - Bos taurus
consumedByEvent	[Reaction:R-BTA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Bos taurus [Reaction:R-BTA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Bos taurus [Reaction:R-BTA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10404671
displayName	MAP2K1 dimer [cytosol]
hasComponent	2 × [EntityWithAccessionedSequence:R-BTA-59502] MAP2K1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5672683] MAP2K1 dimer [cytosol] - Homo sapiens [DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol] - Homo sapiens
maxDepth	2
name	MAP2K1 dimer
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-5672683
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-BTA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components [Reaction:R-BTA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome [Reaction:R-BTA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
(hasComponent)	[Complex:R-BTA-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] [Complex:R-BTA-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] [Complex:R-BTA-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
(activeUnit)	[CatalystActivity:10432050] protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
(inferredTo)	[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol] [Complex:R-HSA-5672683] MAP2K1 dimer [cytosol]

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