Reactome | MAP2Ks and MAPKs bind to the activated RAF complex

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MAP2Ks and MAPKs bind to the activated RAF complex Show undefined attributes

authored	[InstanceEdit:5658468] Rothfels, Karen, 2014-12-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5672971] Rothfels, Karen, 2015-02-06
dbId	5672972
displayName	MAP2Ks and MAPKs bind to the activated RAF complex
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5674135] MAP2K and MAPK activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5672978] RAF phosphorylates MAP2K dimer - Homo sapiens [Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Homo sapiens
input	[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169291] MAPKs [cytosol] [Complex:R-HSA-5672718] p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] [CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5674433] Mek2 is dispensable for mouse growth and development [LiteratureReference:5674429] Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta [LiteratureReference:5673967] Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition [LiteratureReference:5673933] A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal [LiteratureReference:110038] A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:5673960] MEK1/2 dual-specificity protein kinases: structure and regulation [LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation [LiteratureReference:5673962] Protein scaffolds in MAP kinase signalling [LiteratureReference:5673947] IQGAP1 binds ERK2 and modulates its activity [LiteratureReference:5673950] IQGAP1 is a scaffold for mitogen-activated protein kinase signaling [LiteratureReference:5673951] IQGAP1 modulates activation of B-Raf [LiteratureReference:5673975] beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2 [LiteratureReference:5673972] The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation [LiteratureReference:5674381] Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis [LiteratureReference:208331] KSR and CNK: two scaffolds regulating RAS-mediated RAF activation [LiteratureReference:208164] Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression [LiteratureReference:208057] Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling [LiteratureReference:5673957] Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization [LiteratureReference:5674347] ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	MAP2Ks and MAPKs bind to the activated RAF complex
orthologousEvent	[Reaction:R-MMU-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Mus musculus [Reaction:R-RNO-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Rattus norvegicus [Reaction:R-CFA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Canis familiaris [Reaction:R-BTA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Bos taurus [Reaction:R-SSC-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Sus scrofa [Reaction:R-GGA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Gallus gallus [Reaction:R-DME-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Drosophila melanogaster [Reaction:R-CEL-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Caenorhabditis elegans
output	[Complex:R-HSA-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-5672969] Phosphorylation of RAF - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5675436] Negative regulation by 'p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane]'
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672972
summation	[Summation:5672603] RAF kinases have restricted substrate specificity and have a...

Referrals

(precedingEvent)	[Reaction:R-HSA-5672978] RAF phosphorylates MAP2K dimer [Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks
(hasEvent)	[Pathway:R-HSA-5674135] MAP2K and MAPK activation
(normalReaction)	[Reaction:R-HSA-6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs [Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex [Reaction:R-HSA-6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs [Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs [Reaction:R-HSA-6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs [Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs

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