Reactome | MAP2K homo/heterodimers [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Drosophila melanogaster [Reaction:R-DME-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Drosophila melanogaster [Reaction:R-DME-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10881358
displayName	MAP2K homo/heterodimers [cytosol]
hasMember	[Complex:R-DME-5672683] MAP2K1 dimer [cytosol] - Drosophila melanogaster [Complex:R-DME-5672686] MAP2K1:MAPK2K2 heterodimer [cytosol] - Drosophila melanogaster [Complex:R-DME-5672685] MAP2K2 dimer [cytosol] - Drosophila melanogaster
inDisease	false
inferredFrom	[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol] - Homo sapiens
maxDepth	3
name	MAP2K homo/heterodimers
schemaClass	DefinedSet
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5672716

(input)	[Reaction:R-DME-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components [Reaction:R-DME-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome [Reaction:R-DME-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
(hasComponent)	[Complex:R-DME-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] [Complex:R-DME-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] [Complex:R-DME-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
(activeUnit)	[CatalystActivity:10902860] protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
(inferredTo)	[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol]