Reactome | MAP2Ks and MAPKs bind to the activated mutant RAF1 complex

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MAP2Ks and MAPKs bind to the activated mutant RAF1 complex Show undefined attributes

authored	[InstanceEdit:9664643] Rothfels, Karen, 2019-10-25
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9656210] Rothfels, Karen, 2019-07-27
crossReference	[DatabaseIdentifier:12020787] Mondo:0005045
dbId	9656211
disease	[Disease:9651116] Costello syndrome [Disease:9651118] LEOPARD syndrome [Disease:6802289] Noonan syndrome [Disease:1500689] cancer [Disease:6788675] hypertrophic cardiomyopathy
displayName	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
edited	[InstanceEdit:9690121] Rothfels, Karen, 2020-05-26
entityFunctionalStatus	[EntityFunctionalStatus:9656204] gain_of_function of p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]
eventOf	[Pathway:R-HSA-9656223] Signaling by RAF1 mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-9656215] RAF1 mutant complexes phosphorylate MAP2K dimer - Homo sapiens
input	[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169291] MAPKs [cytosol] [Complex:R-HSA-9656176] p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane] [CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6790423] The RASopathies
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
normalReaction	[Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
output	[Complex:R-HSA-9656179] activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane]
precedingEvent	[Reaction:R-HSA-9656212] Phosphorylation of RAF1 mutants - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9656211
summation	[Summation:9655944] MAP2K and MAPK proteins are likely recruited to complexes co...

Referrals

(precedingEvent)	[Reaction:R-HSA-9656215] RAF1 mutant complexes phosphorylate MAP2K dimer
(hasEvent)	[Pathway:R-HSA-9656223] Signaling by RAF1 mutants

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