Reactome | RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs

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RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802917] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802914
disease	[Disease:1500689] cancer
displayName	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:6802874] gain_of_function of RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
eventOf	[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-6802919] RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks - Homo sapiens
input	[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169291] MAPKs [cytosol] [CandidateSet:R-HSA-5672717] RAF/MAPK scaffolds [cytosol] [Complex:R-HSA-6802642] RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling [LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling [LiteratureReference:6790417] Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond [LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
normalReaction	[Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
output	[Complex:R-HSA-6802645] RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
precedingEvent	[Reaction:R-HSA-6802916] RAF is phosphorylated downstream of moderate kinase activity BRAF mutants - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8936742] Negative regulation by 'p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane]'
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802914
summation	[Summation:6802230] RAF dimerization and phosphorylation downstream of moderatel...

Referrals

(hasEvent)	[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants
(precedingEvent)	[Reaction:R-HSA-6802919] RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks

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