Reactome | FADD [cytosol]

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5637464] TNFSF10:TNFRSF10A,B:FADD [plasma membrane] - Homo sapiens [Complex:R-HSA-5637464] TNFSF10:TNFRSF10A,B:FADD [plasma membrane] - Homo sapiens [Complex:R-HSA-43124] FASL:FAS Receptor Trimer:FADD [plasma membrane] - Homo sapiens [Complex:R-HSA-43124] FASL:FAS Receptor Trimer:FADD [plasma membrane] - Homo sapiens [Complex:R-HSA-918291] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane] - Homo sapiens [Complex:R-HSA-9693918] TRADD:TRAF2:RIPK1 variant:FADD [cytosol] - Homo sapiens [Complex:R-HSA-9693918] TRADD:TRAF2:RIPK1 variant:FADD [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-75187] TRAIL:TRAIL receptor trimers bind FADD - Homo sapiens [Reaction:R-HSA-75187] TRAIL:TRAIL receptor trimers bind FADD - Homo sapiens [Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD - Homo sapiens [Reaction:R-HSA-83650] FasL:Fas binds FADD - Homo sapiens [Reaction:R-HSA-83650] FasL:Fas binds FADD - Homo sapiens [Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD - Homo sapiens [Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD - Homo sapiens [Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly - Homo sapiens [Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly - Homo sapiens [Reaction:R-HSA-2562541] TLR4-induced ripoptosome assembly - Homo sapiens [Reaction:R-HSA-2562541] TLR4-induced ripoptosome assembly - Homo sapiens
dbId	54639
displayName	FADD [cytosol]
endCoordinate	208
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-54639] Fadd [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-54639] Fadd [cytosol] - Rattus norvegicus [GenomeEncodedEntity:R-CFA-54639] Ghost homologue of FADD [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-54639] FADD [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-54639] FADD [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-54639] fadd [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-GGA-54639] FADD [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-54639] Fadd [cytosol] - Drosophila melanogaster
literatureReference	[LiteratureReference:140483] FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
maxDepth	1
modified	[InstanceEdit:3132750] Wu, G, 2013-02-13
name	FADD FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity) FADD protein FAS-associating death domain-containing protein Mediator of receptor induced toxicity
referenceEntity	[ReferenceGeneProduct:uniprot:Q13158] UniProt:Q13158 FADD
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-54639
startCoordinate	1
updateTrackers	[UpdateTracker:9879847] Update Tracker - [EntityWithAccessionedSequence:54639] FADD [cytosol] - v44:[modifyEndCoordinate]

(updatedInstance)	[UpdateTracker:9879847] Update Tracker - [EntityWithAccessionedSequence:54639] FADD [cytosol] - v44:[modifyEndCoordinate]
(hasComponent)	[Complex:R-HSA-9693918] TRADD:TRAF2:RIPK1 variant:FADD [cytosol] [Complex:R-HSA-5357809] TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] [Complex:R-HSA-5637464] TNFSF10:TNFRSF10A,B:FADD [plasma membrane] [Complex:R-HSA-43124] FASL:FAS Receptor Trimer:FADD [plasma membrane] [Complex:R-HSA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] [Complex:R-HSA-9013893] activated TLR3:TRIF:RIP1:FADD [endosome membrane] [Complex:R-HSA-9013891] activated TLR3:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Complex:R-HSA-2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] [Complex:R-HSA-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] [Complex:R-HSA-933480] FADD:Casp-8/10 prodomain [cytosol] [Complex:R-HSA-918291] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD [mitochondrial outer membrane]
(input)	[Reaction:R-HSA-83650] FasL:Fas binds FADD [Reaction:R-HSA-75187] TRAIL:TRAIL receptor trimers bind FADD [Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD [Reaction:R-HSA-9013889] TLR3-induced ripoptosome assembly [Reaction:R-HSA-2562541] TLR4-induced ripoptosome assembly [Reaction:R-HSA-168934] MAVS interacts with RIPK1 and FADD

FADD [cytosol] Show undefined attributes

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