Reactome | TRADD:TRAF2:RIPK1:FADD [cytosol]

Schema > Complex > Entries

TRADD:TRAF2:RIPK1:FADD [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] - Homo sapiens [Complex:R-HSA-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] - Homo sapiens [Complex:R-HSA-9697746] TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] - Homo sapiens
consumedByEvent	[BlackBoxEvent:R-HSA-5357828] RIPK1 is cleaved by CASP8 - Homo sapiens [Reaction:R-HSA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Homo sapiens [Reaction:R-HSA-75240] TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 - Homo sapiens
created	[InstanceEdit:140974] Gillespie, ME, 2004-08-25 17:28:36
dbId	140977
displayName	TRADD:TRAF2:RIPK1:FADD [cytosol]
goCellularComponent	[GO_CellularComponent:161217] death-inducing signaling complex
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-54639] FADD [cytosol] [Complex:R-HSA-140935] TRAF2:TRADD:RIPK1 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Mus musculus [Complex:R-RNO-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Rattus norvegicus [Complex:R-CFA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Canis familiaris [Complex:R-BTA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Bos taurus [Complex:R-SSC-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Sus scrofa [Complex:R-DRE-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Danio rerio [Complex:R-GGA-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Gallus gallus [Complex:R-DME-140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - Drosophila melanogaster
literatureReference	[LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes [LiteratureReference:3465531] Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
maxDepth	3
memberOf	[DefinedSet:R-HSA-2671814] DISC [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	TRADD:TRAF2:RIPK1:FADD
producedByEvent	[Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-140977
updateTrackers	[UpdateTracker:9884931] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v45:[addLiteratureReference, modifyName, updateContainedComponent] [UpdateTracker:9880091] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v44:[updateContainedComponent] [UpdateTracker:9901588] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v74:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9884931] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v45:[addLiteratureReference, modifyName, updateContainedComponent] [UpdateTracker:9880091] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v44:[updateContainedComponent] [UpdateTracker:9901588] Update Tracker - [Complex:140977] TRADD:TRAF2:RIPK1:FADD [cytosol] - v74:[modifyName]
(normalEntity)	[EntityFunctionalStatus:9693921] loss_of_function of TRADD:TRAF2:RIPK1 variant:FADD [cytosol]
(hasComponent)	[Complex:R-HSA-9697746] TRADD:TRAF2:RIPK1:FADD:p43/p41CASP8:p43 FLIP(L) [plasma membrane] [Complex:R-HSA-3465532] TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] [Complex:R-HSA-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] [Complex:R-HSA-2671812] TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol]
(input)	[Reaction:R-HSA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling [BlackBoxEvent:R-HSA-5357828] RIPK1 is cleaved by CASP8 [Reaction:R-HSA-75240] TRADD:TRAF2:RIP1:FADD binds pro-caspase 8
(output)	[Reaction:R-HSA-140978] TRADD:TRAF2:RIP1 binds FADD
(hasMember)	[DefinedSet:R-HSA-2671814] DISC [plasma membrane]

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