Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

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BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 Show undefined attributes

authored	[InstanceEdit:500697] Matthews, L, 2010-02-04
category	binding
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:508156] Matthews, L, 2010-02-10
dbId	508163
deleted	[Deleted:622298] Deletion of instance: 114277 [Deleted:508169] Deletion of instance: 114279 [Deleted:508176] Deletion of instance: 114241 [Deleted:508171] Deletion of instance: 140230
displayName	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
eventOf	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Homo sapiens
input	[CandidateSet:R-HSA-508157] Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-HSA-50757] BCL2 [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:114451] Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed [LiteratureReference:140464] The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex [LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53 [LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis [LiteratureReference:140457] Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death [LiteratureReference:140409] Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
orthologousEvent	[Reaction:R-GGA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Gallus gallus [Reaction:R-DRE-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Danio rerio [Reaction:R-SSC-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Sus scrofa [Reaction:R-BTA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Bos taurus [Reaction:R-CFA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Canis familiaris [Reaction:R-MMU-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Mus musculus
output	[Complex:R-HSA-508158] Bcl2:BH3-only protein complex [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-140216] Translocation of PMAIP1 (NOXA) to mitochondria - Homo sapiens [Reaction:R-HSA-139905] Translocation of activated BAD protein to mitochondria - Homo sapiens [Reaction:R-HSA-139920] Translocation of tBID to mitochondria - Homo sapiens [Reaction:R-HSA-139914] Translocation of BBC3 (PUMA) protein to mitochondria - Homo sapiens [Reaction:R-HSA-139919] Translocation of BIM to mitochondria - Homo sapiens [Reaction:R-HSA-139909] Translocation of BMF to mitochondria - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-508163
summation	[Summation:508164] Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath...
updateTrackers	[UpdateTracker:9787603] Update Tracker - [Reaction:508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - v44:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787603] Update Tracker - [Reaction:508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - v44:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:622298] Deletion of instance: 114277 [Deleted:508169] Deletion of instance: 114279 [Deleted:508176] Deletion of instance: 114241 [Deleted:508171] Deletion of instance: 140230
(hasEvent)	[Pathway:R-HSA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

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