Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

Schema > Reaction > Entries

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 Show undefined attributes

category	binding
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10761995
displayName	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
eventOf	[Pathway:R-GGA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Homo sapiens
input	[CandidateSet:R-GGA-508157] Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] [EntityWithAccessionedSequence:R-GGA-50757] BCL2 [mitochondrial outer membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
output	[Complex:R-GGA-508158] Bcl2:BH3-only protein complex [mitochondrial outer membrane]
precedingEvent	[Reaction:R-GGA-140216] Translocation of PMAIP1 (NOXA) to mitochondria - Gallus gallus [Reaction:R-GGA-139920] Translocation of tBID to mitochondria - Gallus gallus [Reaction:R-GGA-139919] Translocation of BIM to mitochondria - Gallus gallus [Reaction:R-GGA-139909] Translocation of BMF to mitochondria - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-508163
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
(inferredTo)	[Reaction:R-HSA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

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