Reactome | Translocation of activated BAD protein to mitochondria

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Translocation of activated BAD protein to mitochondria Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
dbId	139905
displayName	Translocation of activated BAD protein to mitochondria
eventOf	[Pathway:R-HSA-111447] Activation of BAD and translocation to mitochondria - Homo sapiens
followingEvent	[Reaction:R-HSA-139897] BAD displaces tBID from BCL-2 sequestration - Homo sapiens [Reaction:R-HSA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Homo sapiens [Reaction:R-HSA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161847] protein insertion into mitochondrial membrane
input	[EntityWithAccessionedSequence:R-HSA-50662] BAD [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:114467] Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	Translocation of activated BAD protein to mitochondria
orthologousEvent	[Reaction:R-XTR-139905] Translocation of activated BAD protein to mitochondria - Xenopus tropicalis [Reaction:R-DRE-139905] Translocation of activated BAD protein to mitochondria - Danio rerio [Reaction:R-SSC-139905] Translocation of activated BAD protein to mitochondria - Sus scrofa [Reaction:R-BTA-139905] Translocation of activated BAD protein to mitochondria - Bos taurus [Reaction:R-CFA-139905] Translocation of activated BAD protein to mitochondria - Canis familiaris [Reaction:R-RNO-139905] Translocation of activated BAD protein to mitochondria - Rattus norvegicus [Reaction:R-MMU-139905] Translocation of activated BAD protein to mitochondria - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-114242] BAD [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-139906] Activation of BAD by calcineurin - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-139905
summation	[Summation:179254] Dephosphorylated BAD translocates to the outer mitochondrial...
updateTrackers	[UpdateTracker:9788003] Update Tracker - [Reaction:139905] Translocation of activated BAD protein to mitochondria - v44:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788003] Update Tracker - [Reaction:139905] Translocation of activated BAD protein to mitochondria - v44:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL [Reaction:R-HSA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 [Reaction:R-HSA-139897] BAD displaces tBID from BCL-2 sequestration
(hasEvent)	[Pathway:R-HSA-111447] Activation of BAD and translocation to mitochondria