Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

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BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Show undefined attributes

compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
crossReference	[DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819581] BioModels Database:BIOMD0000000943
dbId	111453
displayName	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
eventOf	[Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2133703] positive regulation of intrinsic apoptotic signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-6790025] Expression of BCL2, BCL2L1 - Homo sapiens [Reaction:R-HSA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Homo sapiens [Reaction:R-HSA-9692376] BCL2 binds BCL2 antagonists - Homo sapiens [Reaction:R-HSA-114352] Sequestration of tBID by BCL-2 - Homo sapiens [Reaction:R-HSA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
orthologousEvent	[Pathway:R-CEL-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Caenorhabditis elegans [Pathway:R-GGA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Gallus gallus [Pathway:R-XTR-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Xenopus tropicalis [Pathway:R-DRE-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Danio rerio [Pathway:R-SSC-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Sus scrofa [Pathway:R-BTA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Bos taurus [Pathway:R-CFA-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Canis familiaris [Pathway:R-RNO-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Rattus norvegicus [Pathway:R-MMU-111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - Mus musculus
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-111453
summation	[Summation:9028950] Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath...
updateTrackers	[UpdateTracker:9775853] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v78:[updateContainedRLE] [UpdateTracker:9787774] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v44:[updateContainedRLE] [UpdateTracker:9790553] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v33:[addHasEvent] [UpdateTracker:9776348] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v76:[updateContainedRLE] [UpdateTracker:9774735] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v81:[addHasEvent] [UpdateTracker:9779751] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v64:[addHasEvent] [UpdateTracker:9791157] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v32:[add_removeHasEvent] [UpdateTracker:9780215] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v63:[addSummation]

Referrals

(updatedInstance)

[UpdateTracker:9775853] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v78:[updateContainedRLE]
[UpdateTracker:9787774] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v44:[updateContainedRLE]
[UpdateTracker:9790553] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v33:[addHasEvent]
[UpdateTracker:9776348] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v76:[updateContainedRLE]
[UpdateTracker:9774735] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v81:[addHasEvent]
[UpdateTracker:9779751] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v64:[addHasEvent]
[UpdateTracker:9791157] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v32:[add_removeHasEvent]
[UpdateTracker:9780215] Update Tracker - [Pathway:111453] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members - v63:[addSummation]

(hasEvent)

[Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis

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