BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

Stable Identifier
Reaction [binding]
Homo sapiens
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Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath et al. 1999), PUMA (Nakano and Vousden 2001), NOXA (Oda et al. 2000), BAD (Yang et al. 2005), BMF (Puthalakath et al. 2001), resulting in inactivation of BCL2.

Literature References
PubMed ID Title Journal Year
7834748 Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

Yang, E, Zha, J, Jockel, J, Boise, LH, Thompson, CB, Korsmeyer, SJ

Cell 1995
11546872 Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

Puthalakath, H, Villunger, A, O'Reilly, LA, Beaumont, JG, Coultas, L, Cheney, RE, Huang, DC, Strasser, A

Science 2001
10198631 The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

Puthalakath, H, Huang, DC, O'Reilly, LA, King, SM, Strasser, A

Mol Cell 1999
12624108 Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Yi, X, Yin, XM, Dong, Z

J Biol Chem 2003
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Oda, E, Ohki, R, Murasawa, H, Nemoto, J, Shibue, T, Yamashita, T, Tokino, T, Taniguchi, T, Tanaka, N

Science 2000
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
Participant Of
Orthologous Events
Cross References
Target Pathogen
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