Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

Stable Identifier

R-HSA-508163

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath et al. 1999), PUMA (Nakano and Vousden 2001), NOXA (Oda et al. 2000), BAD (Yang et al. 2005), BMF (Puthalakath et al. 2001), resulting in inactivation of BCL2.

Literature References

PubMed ID	Title	Journal	Year
7834748	Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death Yang, E, Zha, J, Jockel, J, Boise, LH, Thompson, CB, Korsmeyer, SJ	Cell	1995
11546872	Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis Puthalakath, H, Villunger, A, O'Reilly, LA, Beaumont, JG, Coultas, L, Cheney, RE, Huang, DC, Strasser, A	Science	2001
10198631	The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex Puthalakath, H, Huang, DC, O'Reilly, LA, King, SM, Strasser, A	Mol Cell	1999
12624108	Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed Yi, X, Yin, XM, Dong, Z	J Biol Chem	2003
10807576	Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis Oda, E, Ohki, R, Murasawa, H, Nemoto, J, Shibue, T, Yamashita, T, Tokino, T, Taniguchi, T, Tanaka, N	Science	2000
11463392	PUMA, a novel proapoptotic gene, is induced by p53 Nakano, K, Vousden, KH	Mol Cell	2001