Reactome | Translocation of BIM to mitochondria

Schema > Reaction > Entries

Translocation of BIM to mitochondria Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:139911] Hardwick, JM, Tsujimoto, Y, 2004-08-09 19:10:09
dbId	139919
displayName	Translocation of BIM to mitochondria
eventOf	[Pathway:R-HSA-111446] Activation of BIM and translocation to mitochondria - Homo sapiens
followingEvent	[Reaction:R-HSA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL - Homo sapiens [Reaction:R-HSA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161847] protein insertion into mitochondrial membrane
input	[EntityWithAccessionedSequence:R-HSA-140525] p-BCL2L11 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:140464] The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Translocation of BIM to mitochondria
orthologousEvent	[Reaction:R-GGA-139919] Translocation of BIM to mitochondria - Gallus gallus [Reaction:R-SSC-139919] Translocation of BIM to mitochondria - Sus scrofa [Reaction:R-BTA-139919] Translocation of BIM to mitochondria - Bos taurus [Reaction:R-CFA-139919] Translocation of BIM to mitochondria - Canis familiaris [Reaction:R-RNO-139919] Translocation of BIM to mitochondria - Rattus norvegicus [Reaction:R-MMU-139919] Translocation of BIM to mitochondria - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3145027] p-BCL2L11 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-HSA-139918] Phosphorylation of BIM by JNK - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-139919
summation	[Summation:179256] Once BCL2L11 (BIM) dissociates from the cytoskeleton, it tra...
updateTrackers	[UpdateTracker:9787611] Update Tracker - [Reaction:139919] Translocation of BIM to mitochondria - v44:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787611] Update Tracker - [Reaction:139919] Translocation of BIM to mitochondria - v44:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(precedingEvent)	[Reaction:R-HSA-508162] BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL [Reaction:R-HSA-508163] BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
(hasEvent)	[Pathway:R-HSA-111446] Activation of BIM and translocation to mitochondria