Reactome | Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath...

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created	[InstanceEdit:508156] Matthews, L, 2010-02-10
dbId	508164
displayName	Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath...
literatureReference	[LiteratureReference:114451] Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed [LiteratureReference:140464] The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex [LiteratureReference:140450] PUMA, a novel proapoptotic gene, is induced by p53 [LiteratureReference:140387] Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis [LiteratureReference:140457] Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death [LiteratureReference:140409] Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
modified	[InstanceEdit:3145741] Orlic-Milacic, M, 2013-02-14
schemaClass	Summation
text	Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath et al. 1999), PUMA (Nakano and Vousden 2001), NOXA (Oda et al. 2000), BAD (Yang et al. 2005), BMF (Puthalakath et al. 2001), resulting in inactivation of BCL2.

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