Reactome | Beta-catenin is released from the destruction complex

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Beta-catenin is released from the destruction complex Show undefined attributes

authored	[InstanceEdit:3632861] Rothfels, K, 2013-05-27
category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:201703] Matthews, L, 2007-09-10 21:56:08
dbId	201685
displayName	Beta-catenin is released from the destruction complex
edited	[InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29 [InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens [Reaction:R-HSA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Homo sapiens
input	[Complex:R-HSA-4416737] CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208113] Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex [LiteratureReference:4641111] Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex [LiteratureReference:5228664] Wnt/beta-catenin signaling: new (and old) players and new insights [LiteratureReference:3772368] The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization [LiteratureReference:2130277] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation [LiteratureReference:3238089] The way Wnt works: Components and mechanism [LiteratureReference:5323421] Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling [LiteratureReference:5323463] Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes [LiteratureReference:5323465] Wnt signaling: multivesicular bodies hold GSK3 captive [LiteratureReference:5323441] Membrane trafficking: a GSK3 lockdown
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Beta-catenin is released from the destruction complex
orthologousEvent	[Reaction:R-SSC-201685] Beta-catenin is released from the destruction complex - Sus scrofa [Reaction:R-BTA-201685] Beta-catenin is released from the destruction complex - Bos taurus [Reaction:R-CFA-201685] Beta-catenin is released from the destruction complex - Canis familiaris [Reaction:R-RNO-201685] Beta-catenin is released from the destruction complex - Rattus norvegicus [Reaction:R-MMU-201685] Beta-catenin is released from the destruction complex - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-1504189] AMER1 [cytosol] [EntityWithAccessionedSequence:R-HSA-195263] CSNK1A1 [cytosol] [EntityWithAccessionedSequence:R-HSA-448839] CTNNB1 [cytosol] [Complex:R-HSA-1504204] GSK3B:AXIN1 [cytosol] [EntityWithAccessionedSequence:R-HSA-5246690] K63polyUb-APC [cytosol] [Complex:R-HSA-196206] PP2A [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-3601585] PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex - Homo sapiens [Reaction:R-HSA-201691] Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8981436] Positive regulation by 'WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane]'
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201685
summation	[Summation:3640818] Stimulation of the WNT pathway results in the recruitment of...
updateTrackers	[UpdateTracker:9786597] Update Tracker - [Reaction:201685] Beta-catenin is released from the destruction complex - v49:[add_removeOutput] [UpdateTracker:9781159] Update Tracker - [Reaction:201685] Beta-catenin is released from the destruction complex - v61:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786597] Update Tracker - [Reaction:201685] Beta-catenin is released from the destruction complex - v49:[add_removeOutput] [UpdateTracker:9781159] Update Tracker - [Reaction:201685] Beta-catenin is released from the destruction complex - v61:[addRegulator]
(hasEvent)	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane
(precedingEvent)	[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus [Reaction:R-HSA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex

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