Reactome | Disassembly of the destruction complex and recruitment of AXIN to the membrane

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Disassembly of the destruction complex and recruitment of AXIN to the membrane Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10648712
displayName	Disassembly of the destruction complex and recruitment of AXIN to the membrane
eventOf	[Pathway:R-DRE-201681] TCF dependent signaling in response to WNT - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259757] canonical Wnt signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-5323526] FRAT proteins bind GSK3beta - Danio rerio [Reaction:R-DRE-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Danio rerio [Reaction:R-DRE-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Danio rerio [BlackBoxEvent:R-DRE-5368596] WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 - Danio rerio
inferredFrom	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Disassembly of the destruction complex and recruitment of AXIN to the membrane
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-4641262
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane

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