Reactome | DVL recruits GSK3beta:AXIN1 to the receptor complex

Schema > Reaction > Entries

DVL recruits GSK3beta:AXIN1 to the receptor complex Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1504208] Rothfels, K, 2011-08-23
dbId	1504186
displayName	DVL recruits GSK3beta:AXIN1 to the receptor complex
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Homo sapiens
input	[Complex:R-HSA-1504204] GSK3B:AXIN1 [cytosol] [Complex:R-HSA-1504192] WNT:FZD:LRP5/6:DVL [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208316] Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway [LiteratureReference:1504200] Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions [LiteratureReference:3772368] The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization [LiteratureReference:2130277] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	DVL recruits GSK3beta:AXIN1 to the receptor complex
orthologousEvent	[Reaction:R-DME-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Drosophila melanogaster [Reaction:R-GGA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Gallus gallus [Reaction:R-DRE-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Danio rerio [Reaction:R-SSC-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Sus scrofa [Reaction:R-BTA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Bos taurus [Reaction:R-CFA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Canis familiaris [Reaction:R-RNO-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Rattus norvegicus [Reaction:R-MMU-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Mus musculus
output	[Complex:R-HSA-1504184] WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
precedingEvent	[Reaction:R-HSA-1504188] FZD recruits DVL to the receptor complex - Homo sapiens [Reaction:R-HSA-201685] Beta-catenin is released from the destruction complex - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1504186
summation	[Summation:1504182] The DIX domains of DVL and AXIN interact and this interactio...

Referrals

(hasEvent)	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane
(precedingEvent)	[Reaction:R-HSA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta