Reactome | FRAT proteins bind GSK3beta

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FRAT proteins bind GSK3beta Show undefined attributes

authored	[InstanceEdit:5263025] Rothfels, K, 2014-02-10
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5323529] Rothfels, K, 2014-02-15
dbId	5323526
displayName	FRAT proteins bind GSK3beta
edited	[InstanceEdit:5323556] Rothfels, K, 2014-02-15
eventOf	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Homo sapiens
input	[DefinedSet:R-HSA-1226058] FRAT1,2 [cytosol] [EntityWithAccessionedSequence:R-HSA-2997551] GSK3B [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5323409] Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas [LiteratureReference:5323452] Re-evaluating the role of Frat in Wnt-signal transduction [LiteratureReference:5323429] GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis [LiteratureReference:5323415] Characterization and functional analysis of the murine Frat2 gene [LiteratureReference:5323404] A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin [LiteratureReference:5323437] Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification [LiteratureReference:5323433] Identification of the Axin and Frat binding region of glycogen synthase kinase-3 [LiteratureReference:5323430] Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin [LiteratureReference:5323460] The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation [LiteratureReference:196219] Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex [LiteratureReference:5323410] Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 [LiteratureReference:5323423] Frat is dispensable for canonical Wnt signaling in mammals [LiteratureReference:5323425] Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways [LiteratureReference:5323426] Frat2 mediates the oncogenic activation of Rac by MLL fusions
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	FRAT proteins bind GSK3beta
orthologousEvent	[Reaction:R-GGA-5323526] FRAT proteins bind GSK3beta - Gallus gallus [Reaction:R-SSC-5323526] FRAT proteins bind GSK3beta - Sus scrofa [Reaction:R-BTA-5323526] FRAT proteins bind GSK3beta - Bos taurus [Reaction:R-CFA-5323526] FRAT proteins bind GSK3beta - Canis familiaris [Reaction:R-RNO-5323526] FRAT proteins bind GSK3beta - Rattus norvegicus [Reaction:R-MMU-5323526] FRAT proteins bind GSK3beta - Mus musculus
output	[Complex:R-HSA-1226052] FRAT1,2:GSK3beta [cytosol]
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5323526
summation	[Summation:5323528] The FRAT genes, which were initially identified as a target ...

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(hasEvent)

[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane

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