Reactome | Disassembly of the destruction complex and recruitment of AXIN to the membrane

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Disassembly of the destruction complex and recruitment of AXIN to the membrane Show undefined attributes

created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10652841
displayName	Disassembly of the destruction complex and recruitment of AXIN to the membrane
eventOf	[Pathway:R-GGA-201681] TCF dependent signaling in response to WNT - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8854801] beta-catenin destruction complex disassembly
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-5323526] FRAT proteins bind GSK3beta - Gallus gallus [Reaction:R-GGA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Gallus gallus [Reaction:R-GGA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Gallus gallus [BlackBoxEvent:R-GGA-5368596] WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 - Gallus gallus
inferredFrom	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Homo sapiens
isInDisease	false
isInferred	true
name	Disassembly of the destruction complex and recruitment of AXIN to the membrane
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-4641262
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane

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