Reactome | Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta

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Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta Show undefined attributes

authored	[InstanceEdit:4415000] Rothfels, K, 2013-08-23
catalystActivity	[CatalystActivity:1505507] protein serine/threonine kinase activity of WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:201703] Matthews, L, 2007-09-10 21:56:08
dbId	201677
displayName	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
edited	[InstanceEdit:201697] Matthews, L, 2007-09-10 12:45:35 [InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-201691] Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1504184] WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208343] A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation [LiteratureReference:208147] A mechanism for Wnt coreceptor activation [LiteratureReference:1458899] Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6 [LiteratureReference:1458867] LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
orthologousEvent	[Reaction:R-CEL-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Caenorhabditis elegans [Reaction:R-DME-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Drosophila melanogaster [Reaction:R-GGA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Gallus gallus [Reaction:R-DRE-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Danio rerio [Reaction:R-SSC-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Sus scrofa [Reaction:R-BTA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Bos taurus [Reaction:R-CFA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Canis familiaris [Reaction:R-RNO-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Rattus norvegicus [Reaction:R-MMU-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Mus musculus
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1458897] WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
precedingEvent	[Reaction:R-HSA-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201677
summation	[Summation:1458879] LRP5/6 contains 5 PPP(S/T)PxS motifs in its intracellular do...

Referrals

(hasEvent)	[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane
(precedingEvent)	[Reaction:R-HSA-201691] Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI

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