Reactome | Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

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Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:450239] MAP kinase kinase activity of p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId	450333
displayName	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Homo sapiens [Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-450269] p38 MAPK:MAPKAPK2,3 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:442893] MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway [LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
orthologousEvent	[Reaction:R-GGA-438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus [Reaction:R-CEL-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Caenorhabditis elegans [Reaction:R-DME-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Drosophila melanogaster [Reaction:R-GGA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus [Reaction:R-DRE-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Danio rerio [Reaction:R-SSC-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Sus scrofa [Reaction:R-BTA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Bos taurus [Reaction:R-RNO-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Rattus norvegicus [Reaction:R-MMU-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Mus musculus
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-450213] p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450333
summation	[Summation:444066] The MAPK level components of this cascade are p38MAPK-alpha,...
updateTrackers	[UpdateTracker:9790026] Update Tracker - [Reaction:450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790026] Update Tracker - [Reaction:450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - v35:[modifyText]
(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation
(precedingEvent)	[Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 [Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2