Reactome | activated TAK1 mediates p38 MAPK activation

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activated TAK1 mediates p38 MAPK activation Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
crossReference	[DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	450302
displayName	activated TAK1 mediates p38 MAPK activation
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:2132772] p38MAPK cascade
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-450346] activated human TAK1 phosphorylates MKK3/MKK6 - Homo sapiens [Reaction:R-HSA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Homo sapiens [Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens [Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Homo sapiens [Reaction:R-HSA-450257] Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2018-03-26
literatureReference	[LiteratureReference:438028] Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction [LiteratureReference:437996] Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes [LiteratureReference:170002] p38 MAPK signalling cascades: ancient roles and new functions [LiteratureReference:8979744] IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	activated TAK1 mediates p38 MAPK activation
orthologousEvent	[Pathway:R-GGA-437980] Activated TAK1 mediates p38 MAP kinase phosphorylation - Gallus gallus [Pathway:R-PFA-450302] activated TAK1 mediates p38 MAPK activation - Plasmodium falciparum [Pathway:R-SCE-450302] activated TAK1 mediates p38 MAPK activation - Saccharomyces cerevisiae [Pathway:R-SPO-450302] activated TAK1 mediates p38 MAPK activation - Schizosaccharomyces pombe [Pathway:R-DDI-450302] activated TAK1 mediates p38 MAPK activation - Dictyostelium discoideum [Pathway:R-CEL-450302] activated TAK1 mediates p38 MAPK activation - Caenorhabditis elegans [Pathway:R-DME-450302] activated TAK1 mediates p38 MAPK activation - Drosophila melanogaster [Pathway:R-GGA-450302] activated TAK1 mediates p38 MAPK activation - Gallus gallus [Pathway:R-XTR-450302] activated TAK1 mediates p38 MAPK activation - Xenopus tropicalis [Pathway:R-DRE-450302] activated TAK1 mediates p38 MAPK activation - Danio rerio [Pathway:R-SSC-450302] activated TAK1 mediates p38 MAPK activation - Sus scrofa [Pathway:R-BTA-450302] activated TAK1 mediates p38 MAPK activation - Bos taurus [Pathway:R-CFA-450302] activated TAK1 mediates p38 MAPK activation - Canis familiaris [Pathway:R-RNO-450302] activated TAK1 mediates p38 MAPK activation - Rattus norvegicus [Pathway:R-MMU-450302] activated TAK1 mediates p38 MAPK activation - Mus musculus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-450302
summation	[Summation:444065] p38 mitogen-activated protein kinase (MAPK) belongs to a hig...
updateTrackers	[UpdateTracker:9789462] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v38:[updateContainedRLE] [UpdateTracker:9790074] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v35:[modifyText, updateContainedRLE] [UpdateTracker:9787034] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v46:[updateContainedRLE] [UpdateTracker:9780124] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v64:[updateContainedRLE] [UpdateTracker:9788201] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v43:[updateContainedRLE] [UpdateTracker:9781521] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v60:[addLiteratureReference]

Referrals

(updatedInstance)

[UpdateTracker:9789462] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v38:[updateContainedRLE]
[UpdateTracker:9790074] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v35:[modifyText, updateContainedRLE]
[UpdateTracker:9787034] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v46:[updateContainedRLE]
[UpdateTracker:9780124] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v64:[updateContainedRLE]
[UpdateTracker:9788201] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v43:[updateContainedRLE]
[UpdateTracker:9781521] Update Tracker - [Pathway:450302] activated TAK1 mediates p38 MAPK activation - v60:[addLiteratureReference]

(hasEvent)

[Pathway:R-HSA-450294] MAP kinase activation

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