Reactome | Phosphorylated MAPKs phosphorylate ATF-2

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Phosphorylated MAPKs phosphorylate ATF-2 Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
catalystActivity	[CatalystActivity:167971] protein serine/threonine kinase activity of Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:168000] Gillespie, ME, 2005-11-10 16:24:09
dbId	168053
displayName	Phosphorylated MAPKs phosphorylate ATF-2
edited	[InstanceEdit:450361] Shamovsky, V, 2009-12-16
eventOf	[Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors - Homo sapiens
followingEvent	[Reaction:R-HSA-8944397] p-T69,T71-ATF2 binds PTEN gene promoter - Homo sapiens [Reaction:R-HSA-168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-450336] ATF2 [nucleoplasm] 2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:170002] p38 MAPK signalling cascades: ancient roles and new functions
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylated MAPKs phosphorylate ATF-2
orthologousEvent	[Reaction:R-SCE-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Saccharomyces cerevisiae [Reaction:R-SPO-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Schizosaccharomyces pombe [Reaction:R-CEL-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Caenorhabditis elegans [Reaction:R-DME-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Drosophila melanogaster [Reaction:R-GGA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Gallus gallus [Reaction:R-DRE-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Danio rerio [Reaction:R-SSC-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Sus scrofa [Reaction:R-BTA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Bos taurus [Reaction:R-CFA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Canis familiaris [Reaction:R-RNO-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Rattus norvegicus [Reaction:R-MMU-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Mus musculus
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-450243] p-T69,T71-ATF2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-450348] Activated human JNKs migrate to nucleoplasm - Homo sapiens [Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens [BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
revised	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-168053
summation	[Summation:179041] At the beginning of this reaction, 1 molecule of 'ATP', and ... [Summation:450338] the Raf?MEK?ERK pathway induces phosphorylation of ATF2 Thr7...
updateTrackers	[UpdateTracker:9789540] Update Tracker - [Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 - v37:[modifyText] [UpdateTracker:9790865] Update Tracker - [Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 - v32:[addSummation, add_removeInput, add_removeOutput] [UpdateTracker:9782233] Update Tracker - [Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789540] Update Tracker - [Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 - v37:[modifyText] [UpdateTracker:9790865] Update Tracker - [Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 - v32:[addSummation, add_removeInput, add_removeOutput] [UpdateTracker:9782233] Update Tracker - [Reaction:168053] Phosphorylated MAPKs phosphorylate ATF-2 - v59:[modifyText]
(precedingEvent)	[Reaction:R-HSA-168440] Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. [Reaction:R-HSA-8944397] p-T69,T71-ATF2 binds PTEN gene promoter
(hasEvent)	[Pathway:R-HSA-450341] Activation of the AP-1 family of transcription factors

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