Reactome | Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

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Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 Show undefined attributes

catalystActivity	[CatalystActivity:10760824] MAP kinase kinase activity of p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10760826
displayName	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
eventOf	[Pathway:R-GGA-450302] activated TAK1 mediates p38 MAPK activation - Gallus gallus [Pathway:R-GGA-2559580] Oxidative Stress Induced Senescence - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Gallus gallus [Reaction:R-GGA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Gallus gallus
inferredFrom	[Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-450269] p38 MAPK:MAPKAPK2,3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-GGA-450213] p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-450333
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-2559580] Oxidative Stress Induced Senescence [Pathway:R-GGA-450302] activated TAK1 mediates p38 MAPK activation
(precedingEvent)	[Reaction:R-GGA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 [Reaction:R-GGA-168053] Phosphorylated MAPKs phosphorylate ATF-2
(inferredTo)	[Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

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