Reactome | Active p38 MAPK phosphorylates MAPKAPK2 or 3

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Active p38 MAPK phosphorylates MAPKAPK2 or 3 Show undefined attributes

authored	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
catalystActivity	[CatalystActivity:450303] protein serine/threonine kinase activity of p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:450323] Shamovsky, V, 2009-12-16
dbId	450222
displayName	Active p38 MAPK phosphorylates MAPKAPK2 or 3
edited	[InstanceEdit:532463] Shamovsky, V, 2010-02-27
eventOf	[Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation - Homo sapiens [Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-450257] Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 - Homo sapiens [Reaction:R-HSA-3229102] p-MAPKAPK3 phosphorylates BMI1 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-450213] p-p38 MAPK: MAPKAPK2,3 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:442930] Catalysis and function of the p38 alpha.MK2a signaling complex [LiteratureReference:442929] Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer [LiteratureReference:187736] Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2 [LiteratureReference:442952] Molecular basis of MAPK-activated protein kinase 2:p38 assembly [LiteratureReference:3779425] Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase [LiteratureReference:3779435] 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region [LiteratureReference:3779424] A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Active p38 MAPK phosphorylates MAPKAPK2 or 3
orthologousEvent	[Reaction:R-GGA-442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Gallus gallus [Reaction:R-PFA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Plasmodium falciparum [Reaction:R-CEL-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Caenorhabditis elegans [Reaction:R-DME-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Drosophila melanogaster [Reaction:R-GGA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Gallus gallus [Reaction:R-DRE-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Danio rerio [Reaction:R-SSC-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Sus scrofa [Reaction:R-BTA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Bos taurus [Reaction:R-RNO-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Rattus norvegicus [Reaction:R-MMU-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Mus musculus
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-450254] p-p38 MAPK:p-MAPKAPK2/3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532466] Gillespie, ME, 2010-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450222
summation	[Summation:444067] Human p38 MAPK alpha forms a complex with MK2 even when the ...
updateTrackers	[UpdateTracker:9786980] Update Tracker - [Reaction:450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v46:[addLiteratureReference, modifyText] [UpdateTracker:9790192] Update Tracker - [Reaction:450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786980] Update Tracker - [Reaction:450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v46:[addLiteratureReference, modifyText] [UpdateTracker:9790192] Update Tracker - [Reaction:450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - v35:[modifyText]
(hasEvent)	[Pathway:R-HSA-2559580] Oxidative Stress Induced Senescence [Pathway:R-HSA-450302] activated TAK1 mediates p38 MAPK activation
(precedingEvent)	[Reaction:R-HSA-450257] Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 [Reaction:R-HSA-3229102] p-MAPKAPK3 phosphorylates BMI1

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