Reactome | activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

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activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 Show undefined attributes

authored	[InstanceEdit:438031] Shamovsky, V, 2009-09-22
catalystActivity	[CatalystActivity:437955] protein serine/threonine/tyrosine kinase activity of phospho MKK3/ phospho MKK6 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:438021] Shamovsky, V, 2009-09-22
dbId	438019
displayName	activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
edited	[InstanceEdit:668815] Shamovsky, V, 2010-05-04
eventOf	[Pathway:R-GGA-437980] Activated TAK1 mediates p38 MAP kinase phosphorylation - Gallus gallus
followingEvent	[Reaction:R-GGA-442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Gallus gallus
inferredFrom	[Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-442951] p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:442901] Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine [LiteratureReference:442893] MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-GGA-442905] phospho -p38 MAPK : MAPKAPK 2 or MAPKAPK3 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-442938] activated MAPK3/MAPK6 migrates to nucleus - Gallus gallus
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:789693] D'Eustachio, P, 2010-05-23
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-438019
summation	[Summation:444066] The MAPK level components of this cascade are p38MAPK-alpha,...

Referrals

(precedingEvent)	[Reaction:R-GGA-442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3
(hasEvent)	[Pathway:R-GGA-437980] Activated TAK1 mediates p38 MAP kinase phosphorylation
(inferredTo)	[Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

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