Reactome | Sialic acid metabolism

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Sialic acid metabolism Show undefined attributes

authored	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
created	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
dbId	4085001
diseasePathways	[Pathway:R-HSA-5663020] Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) - Homo sapiens [Pathway:R-HSA-4085011] Defective GNE causes sialuria, NK and IBM2 - Homo sapiens [Pathway:R-HSA-4341670] Defective NEU1 causes sialidosis - Homo sapiens [Pathway:R-HSA-5619035] Defective SLC17A5 causes Salla disease (SD) and ISSD - Homo sapiens
displayName	Sialic acid metabolism
doi	10.3180/REACT_200874.1
edited	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
eventOf	[Pathway:R-HSA-446219] Synthesis of substrates in N-glycan biosythesis - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-4085021] GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP - Homo sapiens [Reaction:R-HSA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P - Homo sapiens [Reaction:R-HSA-4084976] NANS converts ManNAc-6-P to Neu5Ac-9-P - Homo sapiens [Reaction:R-HSA-4084989] NANP dephosphorylates Neu5Ac-9-P to Neu5Ac - Homo sapiens [BlackBoxEvent:R-HSA-4085020] Cytosolic Neu5Ac translocates to nucleus - Homo sapiens [Reaction:R-HSA-4084982] CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac - Homo sapiens [BlackBoxEvent:R-HSA-4084990] Nuclear CMP-Neu5Ac translocates to cytosol - Homo sapiens [Reaction:R-HSA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Homo sapiens [Reaction:R-HSA-4084984] ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) - Homo sapiens [Reaction:R-HSA-4085033] ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) - Homo sapiens [Reaction:R-HSA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Homo sapiens [Reaction:R-HSA-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Homo sapiens [BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane - Homo sapiens [Reaction:R-HSA-4084994] NEU3 hydrolyzes Neu5Ac from glycoconjugates - Homo sapiens [BlackBoxEvent:R-HSA-4088210] Cytosolic glycoconjugates translocate to the lysosome - Homo sapiens [Reaction:R-HSA-4084999] NEU1 hydrolyses Neu5Ac from glycoconjugates - Homo sapiens [Reaction:R-HSA-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Homo sapiens [BlackBoxEvent:R-HSA-4088205] Plasma membrane glycoconjugates translocate to the cytosol - Homo sapiens [Reaction:R-HSA-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Homo sapiens [Reaction:R-HSA-428585] SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol - Homo sapiens [Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:4088193] Sialic acid metabolism and sialyltransferases: natural functions and applications [LiteratureReference:4088195] Primer on genes encoding enzymes in sialic acid metabolism in mammals
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Sialic acid metabolism
orthologousEvent	[Pathway:R-MMU-4085001] Sialic acid metabolism - Mus musculus [Pathway:R-RNO-4085001] Sialic acid metabolism - Rattus norvegicus [Pathway:R-CFA-4085001] Sialic acid metabolism - Canis familiaris [Pathway:R-SSC-4085001] Sialic acid metabolism - Sus scrofa [Pathway:R-DRE-4085001] Sialic acid metabolism - Danio rerio [Pathway:R-XTR-4085001] Sialic acid metabolism - Xenopus tropicalis [Pathway:R-GGA-4085001] Sialic acid metabolism - Gallus gallus [Pathway:R-DME-4085001] Sialic acid metabolism - Drosophila melanogaster [Pathway:R-CEL-4085001] Sialic acid metabolism - Caenorhabditis elegans [Pathway:R-SPO-4085001] Sialic acid metabolism - Schizosaccharomyces pombe [Pathway:R-PFA-4085001] Sialic acid metabolism - Plasmodium falciparum [Pathway:R-BTA-4085001] Sialic acid metabolism - Bos taurus [Pathway:R-DDI-4085001] Sialic acid metabolism - Dictyostelium discoideum
releaseDate	2014-03-12
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014-01-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4085001
summation	[Summation:4088194] Sialic acids are a family of 9 carbon alpha-keto acids that ...
updateTrackers	[UpdateTracker:9778466] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v68:[addHasEvent, updateContainedRLE] [UpdateTracker:9784697] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v53:[updateContainedRLE] [UpdateTracker:9785568] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v51:[updateContainedRLE] [UpdateTracker:9785031] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v52:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-446219] Synthesis of substrates in N-glycan biosythesis
(hasEncapsulatedEvent)	[Pathway:R-HSA-428157] Sphingolipid metabolism
(normalPathway)	[Pathway:R-HSA-5663020] Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) [Pathway:R-HSA-4085011] Defective GNE causes sialuria, NK and IBM2 [Pathway:R-HSA-4341670] Defective NEU1 causes sialidosis [Pathway:R-HSA-5619035] Defective SLC17A5 causes Salla disease (SD) and ISSD
(updatedInstance)	[UpdateTracker:9778466] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v68:[addHasEvent, updateContainedRLE] [UpdateTracker:9784697] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v53:[updateContainedRLE] [UpdateTracker:9785568] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v51:[updateContainedRLE] [UpdateTracker:9785031] Update Tracker - [Pathway:4085001] Sialic acid metabolism - v52:[updateContainedRLE]

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