Reactome | ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues

Schema > Reaction > Entries

ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues Show undefined attributes

authored	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
catalystActivity	[CatalystActivity:4086289] alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity of ST8SIA1-6 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
dbId	4084978
displayName	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues
edited	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
eventOf	[Pathway:R-HSA-4085001] Sialic acid metabolism - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen] [SimpleEntity:R-ALL-4088006] Neu5Ac-R [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4088004] Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme [LiteratureReference:4087985] A human STX cDNA confers polysialic acid expression in mammalian cells [LiteratureReference:4087971] Cloning and expression of cDNA for a human Sia alpha 2,3Gal beta 1, 4GlcNA:alpha 2,8-sialyltransferase (hST8Sia III) [LiteratureReference:4087992] Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity [LiteratureReference:4088000] Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V)
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues
orthologousEvent	[Reaction:R-GGA-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Gallus gallus [Reaction:R-XTR-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Xenopus tropicalis [Reaction:R-DRE-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Danio rerio [Reaction:R-SSC-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Sus scrofa [Reaction:R-BTA-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Bos taurus [Reaction:R-CFA-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Canis familiaris [Reaction:R-RNO-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Rattus norvegicus [Reaction:R-MMU-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Mus musculus
output	[SimpleEntity:R-ALL-727810] CMP [Golgi lumen] [SimpleEntity:R-ALL-4087982] Neu5Ac-2,8-Neu5Ac-R [Golgi lumen]
precedingEvent	[Reaction:R-HSA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014-01-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4084978
summation	[Summation:4088001] The alpha-2,8-sialyltransferases 1-6 (ST8SIA1-6) are involve...

Referrals

(hasEvent)	[Pathway:R-HSA-4085001] Sialic acid metabolism
(precedingEvent)	[BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane