Reactome | ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)

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ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) Show undefined attributes

authored	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
catalystActivity	[CatalystActivity:4086253] alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity of ST6GALNAC1-6 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
dbId	4084980
displayName	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)
edited	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
eventOf	[Pathway:R-HSA-4085001] Sialic acid metabolism - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen] [SimpleEntity:R-ALL-4086301] GalNAc-R [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4086254] Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens [LiteratureReference:981812] Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells [LiteratureReference:981829] Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV [LiteratureReference:4086271] Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides [LiteratureReference:4086333] Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)
orthologousEvent	[Reaction:R-GGA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Gallus gallus [Reaction:R-XTR-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Xenopus tropicalis [Reaction:R-DRE-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Danio rerio [Reaction:R-SSC-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Sus scrofa [Reaction:R-BTA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Bos taurus [Reaction:R-CFA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Canis familiaris [Reaction:R-RNO-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Rattus norvegicus [Reaction:R-MMU-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Mus musculus
output	[SimpleEntity:R-ALL-727810] CMP [Golgi lumen] [SimpleEntity:R-ALL-4086341] Neu5Ac-2,6-GalNAc-R [Golgi lumen]
precedingEvent	[Reaction:R-HSA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014-01-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4084980
summation	[Summation:4086299] The alpha-2,6-sialyltransferases 1-6 (ST6GALNAC1-6) are able...

Referrals

(hasEvent)	[Pathway:R-HSA-4085001] Sialic acid metabolism
(precedingEvent)	[BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane

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