Reactome | SLC35A1 exchanges CMP-Neu5Ac for CMP

Schema > Reaction > Entries

SLC35A1 exchanges CMP-Neu5Ac for CMP Show undefined attributes

authored	[InstanceEdit:727808] Jassal, Bijay, 2010-05-12
catalystActivity	[CatalystActivity:727806] CMP-N-acetylneuraminate transmembrane transporter activity of SLC35A1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen [Compartment:70101] cytosol
created	[InstanceEdit:727808] Jassal, Bijay, 2010-05-12
crossReference	[DatabaseIdentifier:12667594] RHEA:67724 [DatabaseIdentifier:9974418] RHEA:67724
dbId	727807
diseaseReaction	[FailedReaction:R-HSA-5651942] Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP - Homo sapiens
displayName	SLC35A1 exchanges CMP-Neu5Ac for CMP
edited	[InstanceEdit:727808] Jassal, Bijay, 2010-05-12
eventOf	[Pathway:R-HSA-727802] Transport of nucleotide sugars - Homo sapiens [Pathway:R-HSA-4085001] Sialic acid metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues - Homo sapiens [Reaction:R-HSA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Homo sapiens [Reaction:R-HSA-4085033] ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) - Homo sapiens [Reaction:R-HSA-4084984] ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link) - Homo sapiens [Reaction:R-HSA-9844860] ST3GAL5 transfers NeuNAc to ceramides - Homo sapiens
input	[SimpleEntity:R-ALL-727810] CMP [Golgi lumen] [SimpleEntity:R-ALL-4085435] CMP-Neu5Ac [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:727801] Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family [LiteratureReference:735687] Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SLC35A1 exchanges CMP-Neu5Ac for CMP CMP-N-acetyl-beta-neuraminate(in) + CMP(out) = CMP-N-acetyl-beta-neuraminate(out) + CMP(in) SLC35A1 mediates the antiport of CMP-sialic acid in exchange for CMP
orthologousEvent	[Reaction:R-PFA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Plasmodium falciparum [Reaction:R-SPO-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Schizosaccharomyces pombe [Reaction:R-CEL-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Caenorhabditis elegans [Reaction:R-GGA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Gallus gallus [Reaction:R-XTR-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Xenopus tropicalis [Reaction:R-DRE-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Danio rerio [Reaction:R-SSC-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Sus scrofa [Reaction:R-BTA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Bos taurus [Reaction:R-CFA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Canis familiaris [Reaction:R-RNO-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Rattus norvegicus [Reaction:R-MMU-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Mus musculus
output	[SimpleEntity:R-ALL-109395] CMP [cytosol] [SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen]
precedingEvent	[BlackBoxEvent:R-HSA-4084990] Nuclear CMP-Neu5Ac translocates to cytosol - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:706449] He, L, 2010-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-727807
summation	[Summation:735697] The human gene SLC35A1 encodes the CMP-sialic acid transport...
updateTrackers	[UpdateTracker:9787030] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v46:[modifyText] [UpdateTracker:9785407] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v52:[modifyText] [UpdateTracker:9786925] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v47:[add_removeInput, modifyText] [UpdateTracker:9786751] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v48:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787030] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v46:[modifyText] [UpdateTracker:9785407] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v52:[modifyText] [UpdateTracker:9786925] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v47:[add_removeInput, modifyText] [UpdateTracker:9786751] Update Tracker - [Reaction:727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - v48:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-5651942] Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP
(hasEvent)	[Pathway:R-HSA-727802] Transport of nucleotide sugars [Pathway:R-HSA-4085001] Sialic acid metabolism
(precedingEvent)	[Reaction:R-HSA-9844860] ST3GAL5 transfers NeuNAc to ceramides [Reaction:R-HSA-4084978] ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues [Reaction:R-HSA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) [Reaction:R-HSA-4085033] ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) [Reaction:R-HSA-4084984] ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)

Cite Us!