Reactome | NEU2 hydrolyzes Neu5Ac from glycoconjugates

Schema > Reaction > Entries

NEU2 hydrolyzes Neu5Ac from glycoconjugates Show undefined attributes

authored	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
catalystActivity	[CatalystActivity:1605672] exo-alpha-sialidase activity of NEU2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
dbId	4085029
displayName	NEU2 hydrolyzes Neu5Ac from glycoconjugates
edited	[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
eventOf	[Pathway:R-HSA-4085001] Sialic acid metabolism - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9840581] GM1 localizes to endosome membrane - Homo sapiens [Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate - Homo sapiens [BlackBoxEvent:R-HSA-4085020] Cytosolic Neu5Ac translocates to nucleus - Homo sapiens
input	[DefinedSet:R-ALL-4088202] glycoconjugates [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1605663] Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases [LiteratureReference:4088067] Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	NEU2 hydrolyzes Neu5Ac from glycoconjugates
orthologousEvent	[Reaction:R-GGA-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Gallus gallus [Reaction:R-XTR-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Xenopus tropicalis [Reaction:R-DRE-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Danio rerio [Reaction:R-SSC-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Sus scrofa [Reaction:R-BTA-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Bos taurus [Reaction:R-CFA-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Canis familiaris [Reaction:R-RNO-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Rattus norvegicus [Reaction:R-MMU-4085029] NEU2 hydrolyzes Neu5Ac from glycoconjugates - Mus musculus
output	[DefinedSet:R-ALL-4088123] Gal-R,GalNAc-R,Neu5Ac-R [cytosol] [SimpleEntity:R-ALL-428633] Neu5Ac [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-4088205] Plasma membrane glycoconjugates translocate to the cytosol - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014-01-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4085029
summation	[Summation:4088118] Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9840581] GM1 localizes to endosome membrane [Reaction:R-HSA-4085217] NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate [BlackBoxEvent:R-HSA-4085020] Cytosolic Neu5Ac translocates to nucleus
(hasEvent)	[Pathway:R-HSA-4085001] Sialic acid metabolism