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Schema
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Reaction
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Entries
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP
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authored
[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
catalystActivity
[CatalystActivity:4085221] UDP-N-acetylglucosamine 2-epimerase activity of GNE hexamer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
crossReference
[DatabaseIdentifier:11880050] Rhea:30684
dbId
4085021
displayName
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP
edited
[InstanceEdit:4085031] Jassal, Bijay, 2013-08-01
eventOf
[Pathway:R-HSA-4085001] Sialic acid metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-162756] UDP-GlcNAc [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:4085196] Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis
[LiteratureReference:4085235] UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation
[LiteratureReference:4085212] Mutations in the human UDP-N-acetylglucosamine 2-epimerase gene define the disease sialuria and the allosteric site of the enzyme
[LiteratureReference:4085223] The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy
[LiteratureReference:4085233] Familial distal myopathy with rimmed vacuole and lamellar (myeloid) body formation
[LiteratureReference:4088344] An Italian family with autosomal recessive inclusion-body myopathy and mutations in the GNE gene
[LiteratureReference:4088383] Distal myopathy with rimmed vacuoles (DMRV): new GNE mutations and splice variant
[LiteratureReference:4088396] Distal myopathy with rimmed vacuoles: novel mutations in the GNE gene
[LiteratureReference:4088349] Hereditary inclusion body myopathy: the Middle Eastern genetic cluster
[LiteratureReference:4088395] Nonaka myopathy is caused by mutations in the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase gene (GNE)
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP
GNE hydrolyzes, epimerises UDP-GlcNAc to ManNAc and UDP
orthologousEvent
[Reaction:R-GGA-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Gallus gallus
[Reaction:R-XTR-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Xenopus tropicalis
[Reaction:R-DRE-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Danio rerio
[Reaction:R-SSC-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Sus scrofa
[Reaction:R-BTA-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Bos taurus
[Reaction:R-CFA-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Canis familiaris
[Reaction:R-RNO-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Rattus norvegicus
[Reaction:R-MMU-4085021] GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP - Mus musculus
output
[SimpleEntity:R-ALL-4085214] ManNAc [cytosol]
[SimpleEntity:R-ALL-110096] UDP [cytosol]
releaseDate
2014-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014-01-08
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-4085021
summation
[Summation:4085197] UDP-N-acetylglucosamine 2-epimerase, N-acetylmannosamine kin...
Referrals
(normalReaction)
[FailedReaction:R-HSA-4088338] Defective GNE does not hydrolyse UDP-GlcNAc
(hasEvent)
[Pathway:R-HSA-4085001] Sialic acid metabolism
(precedingEvent)
[Reaction:R-HSA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P
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