Reactome | CD28 dependent PI3K/Akt signaling

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CD28 dependent PI3K/Akt signaling Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911586
displayName	CD28 dependent PI3K/Akt signaling
eventOf	[Pathway:R-DME-389356] Co-stimulation by CD28 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-2316429] PIP3 recruits PDPK1 to the membrane - Drosophila melanogaster [Reaction:R-DME-2317332] PIP3 recruits AKT to the membrane - Drosophila melanogaster [Reaction:R-DME-198640] mTORC2 phosphorylates AKT at S473 - Drosophila melanogaster [Reaction:R-DME-2317314] AKT binds PDPK1 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	CD28 dependent PI3K/Akt signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-389357
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-389356] Co-stimulation by CD28
(inferredTo)	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling

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