Reactome | CD28 dependent PI3K/Akt signaling

Schema > Pathway > Entries

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444430
displayName	CD28 dependent PI3K/Akt signaling
eventOf	[Pathway:R-BTA-389356] Co-stimulation by CD28 - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-388832] PI3K binds CD28 - Bos taurus [Reaction:R-BTA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-BTA-2316429] PIP3 recruits PDPK1 to the membrane - Bos taurus [Reaction:R-BTA-392530] p-S400-Cot phosphorylates NIK - Bos taurus
inferredFrom	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	CD28 dependent PI3K/Akt signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-389357
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-BTA-389356] Co-stimulation by CD28
(inferredTo)	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling

Cite Us!