Reactome | IGF1,2 [extracellular region]

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IGF1,2 [extracellular region] Show undefined attributes

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-381423] IGF:IGFBP5:ALS [extracellular region] - Homo sapiens [Complex:R-HSA-381509] IGF:IGFBP4 [extracellular region] - Homo sapiens [Complex:R-HSA-381536] IGF:IGFBP3:ALS [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-381545] Formation of the IGF:IGFBP5:ALS complex - Homo sapiens [Reaction:R-HSA-381503] IGFBP6 binds IGF forming IGF:IGFBP6 - Homo sapiens [Reaction:R-HSA-381487] IGFBP1 binds IGF forming IGF:IGFBP1 - Homo sapiens [Reaction:R-HSA-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Homo sapiens [Reaction:R-HSA-2404200] IGF1,2 binds IGF1R - Homo sapiens [Reaction:R-HSA-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Homo sapiens [Reaction:R-HSA-381496] Formation of the IGF:IGFBP3:ALS complex - Homo sapiens
created	[InstanceEdit:381505] May, B, 2008-11-19 20:29:10
dbId	381451
deleted	[Deleted:9774065] Deletion of instance: 3006323
displayName	IGF1,2 [extracellular region]
hasMember	[EntityWithAccessionedSequence:R-HSA-2404178] IGF1 [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2404175] IGF2(25-91) [extracellular region] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-381451] IGF1,2 [extracellular region] - Mus musculus [DefinedSet:R-RNO-381451] IGF1,2 [extracellular region] - Rattus norvegicus [DefinedSet:R-CFA-381451] IGF1,2 [extracellular region] - Canis familiaris [DefinedSet:R-BTA-381451] IGF1,2 [extracellular region] - Bos taurus [DefinedSet:R-SSC-2404175-3] Homologues of IGF2(25-91) [extracellular region] - Sus scrofa [DefinedSet:R-DRE-381451] IGF1,2 [extracellular region] - Danio rerio [DefinedSet:R-XTR-381451] IGF1,2 [extracellular region] - Xenopus tropicalis [DefinedSet:R-GGA-381451] IGF1,2 [extracellular region] - Gallus gallus
maxDepth	2
memberOf	[DefinedSet:R-HSA-481033] Platelet alpha granule contents [extracellular region] - Homo sapiens
modified	[InstanceEdit:5252148] May, B, 2014-02-05
name	IGF1,2 Insulin-like Growth Factor
producedByEvent	[Reaction:R-HSA-381466] Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS - Homo sapiens [Reaction:R-HSA-381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS - Homo sapiens [Reaction:R-HSA-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - Homo sapiens [Reaction:R-HSA-381446] Thrombin proteolyzes IGF:IGFBP3:ALS - Homo sapiens [Reaction:R-HSA-381518] PAAP-A proteolyzes IGF:IGFBP4 - Homo sapiens [Reaction:R-HSA-381435] Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS - Homo sapiens [Reaction:R-HSA-381461] Plasmin proteolyzes IGF:IGFBP-3:ALS - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-381451
updateTrackers	[UpdateTracker:9869804] Update Tracker - [DefinedSet:381451] IGF1,2 [extracellular region] - v34:[updateContainedMemberOrCandidate] [UpdateTracker:9872880] Update Tracker - [DefinedSet:381451] IGF1,2 [extracellular region] - v42:[add_removeHasMember, modifyName] [UpdateTracker:9889107] Update Tracker - [DefinedSet:381451] IGF1,2 [extracellular region] - v48:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9869804] Update Tracker - [DefinedSet:381451] IGF1,2 [extracellular region] - v34:[updateContainedMemberOrCandidate] [UpdateTracker:9872880] Update Tracker - [DefinedSet:381451] IGF1,2 [extracellular region] - v42:[add_removeHasMember, modifyName] [UpdateTracker:9889107] Update Tracker - [DefinedSet:381451] IGF1,2 [extracellular region] - v48:[modifyName]
(replacementInstances)	[Deleted:9774065] Deletion of instance: 3006323
(output)	[Reaction:R-HSA-381466] Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS [Reaction:R-HSA-381435] Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS [Reaction:R-HSA-381500] Cathepsin G proteolyzes IGF:IGFBP3:ALS [Reaction:R-HSA-381461] Plasmin proteolyzes IGF:IGFBP-3:ALS [Reaction:R-HSA-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS [Reaction:R-HSA-381446] Thrombin proteolyzes IGF:IGFBP3:ALS [Reaction:R-HSA-381518] PAAP-A proteolyzes IGF:IGFBP4
(input)	[Reaction:R-HSA-381545] Formation of the IGF:IGFBP5:ALS complex [Reaction:R-HSA-381496] Formation of the IGF:IGFBP3:ALS complex [Reaction:R-HSA-381503] IGFBP6 binds IGF forming IGF:IGFBP6 [Reaction:R-HSA-381412] IGFBP2 binds IGF forming IGF:IGFBP2 [Reaction:R-HSA-381487] IGFBP1 binds IGF forming IGF:IGFBP1 [Reaction:R-HSA-381543] IGFBP4 binds IGF forming IGF:IGFBP4 [Reaction:R-HSA-2404200] IGF1,2 binds IGF1R
(hasComponent)	[Complex:R-HSA-381423] IGF:IGFBP5:ALS [extracellular region] [Complex:R-HSA-381536] IGF:IGFBP3:ALS [extracellular region] [Complex:R-HSA-381482] IGF:IGFBP6 [extracellular region] [Complex:R-HSA-381473] IGF:IGFBP2 [extracellular region] [Complex:R-HSA-381539] IGF:IGFBP1 [extracellular region] [Complex:R-HSA-381509] IGF:IGFBP4 [extracellular region] [Complex:R-HSA-2404189] IGF1,2:p-3Y-IGF1R [plasma membrane] [Complex:R-HSA-2404186] IGF1,2:IGF1R [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-481033] Platelet alpha granule contents [extracellular region]

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