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IGF1,2 [extracellular region]
Stable Identifier
R-HSA-381451
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Insulin-like Growth Factor
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP5:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP1 [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP2 [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP4 [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP6 [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP4 [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP5:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1,2 binds IGF1R (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:IGF1R autophosphorylates (Homo sapiens)
IGF1,2:IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-IGF1R:IRS1,4 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-IGF1R:IRS2 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)
IGF1,2:p-IGF1R:IRS1,2,4 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
SHC-related events triggered by IGF1R (Homo sapiens)
IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1R phosphorylates SHC1 (Homo sapiens)
IGF1,2:p-3Y-IGF1R:SHC1 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
p-3Y-SHC1 dissociates from IGF1R (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF1,2 [extracellular region] (Homo sapiens)
Participants
members
IGF1 [extracellular region]
(Homo sapiens)
IGF2(25-91) [extracellular region]
(Homo sapiens)
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
as an input of
IGF1,2 binds IGF1R (Homo sapiens)
Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)
Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)
IGFBP1 binds IGF forming IGF:IGFBP1 (Homo sapiens)
IGFBP4 binds IGF forming IGF:IGFBP4 (Homo sapiens)
IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)
IGFBP2 binds IGF forming IGF:IGFBP2 (Homo sapiens)
as a component of
IGF1,2:IGF1R [plasma membrane] (Homo sapiens)
IGF1,2:p-3Y-IGF1R [plasma membrane] (Homo sapiens)
IGF:IGFBP5:ALS [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGF:IGFBP1 [extracellular region] (Homo sapiens)
IGF:IGFBP4 [extracellular region] (Homo sapiens)
IGF:IGFBP6 [extracellular region] (Homo sapiens)
IGF:IGFBP2 [extracellular region] (Homo sapiens)
as an output of
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)
PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)
Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
PAAP-A proteolyzes IGF:IGFBP4 (Homo sapiens)
Inferred To
IGF1,2 [extracellular region]
(Bos taurus)
IGF1,2 [extracellular region]
(Canis familiaris)
IGF1,2 [extracellular region]
(Danio rerio)
IGF1,2 [extracellular region]
(Gallus gallus)
IGF1,2 [extracellular region]
(Mus musculus)
IGF1,2 [extracellular region]
(Rattus norvegicus)
IGF1,2 [extracellular region]
(Sus scrofa)
IGF1,2 [extracellular region]
(Xenopus tropicalis)
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