Reactome | Formation of the IGF:IGFBP5:ALS complex

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Formation of the IGF:IGFBP5:ALS complex Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:381505] May, B, 2008-11-19 20:29:10
dbId	381545
displayName	Formation of the IGF:IGFBP5:ALS complex
edited	[InstanceEdit:381443] May, B, Gopinathrao, G, 2008-11-19 20:02:07
eventOf	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
followingEvent	[Reaction:R-HSA-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - Homo sapiens
input	[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region] [EntityWithAccessionedSequence:R-HSA-381498] IGFALS [extracellular region] [EntityWithAccessionedSequence:R-HSA-381414] IGFBP5 [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:381441] Molecular distribution of IGF binding protein-5 in human serum [LiteratureReference:535671] Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 [LiteratureReference:535663] Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes [LiteratureReference:535695] Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography [LiteratureReference:535650] Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting [LiteratureReference:535686] The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers [LiteratureReference:535690] Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding [LiteratureReference:535657] Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6 [LiteratureReference:535681] A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit [LiteratureReference:535679] Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain [LiteratureReference:535677] Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit [LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins [LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms [LiteratureReference:381401] The role of insulin-like growth factor binding proteins
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Formation of the IGF:IGFBP5:ALS complex
orthologousEvent	[Reaction:R-DRE-381545] Formation of the IGF:IGFBP5:ALS complex - Danio rerio [Reaction:R-RNO-381545] Formation of the IGF:IGFBP5:ALS complex - Rattus norvegicus
output	[Complex:R-HSA-381423] IGF:IGFBP5:ALS [extracellular region]
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-381545
summation	[Summation:381548] IGFBP 5 binds IGF I or IGF II via the conserved N terminus a...
updateTrackers	[UpdateTracker:9779923] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v64:[removeCatalystActivity] [UpdateTracker:9790349] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v33:[add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9779923] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v64:[removeCatalystActivity] [UpdateTracker:9790349] Update Tracker - [Reaction:381545] Formation of the IGF:IGFBP5:ALS complex - v33:[add_removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
(precedingEvent)	[Reaction:R-HSA-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS

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