Reactome | IGF1,2 [extracellular region]

Schema > DefinedSet > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-XTR-381473] IGF:IGFBP2 [extracellular region] - Xenopus tropicalis [Complex:R-XTR-381509] IGF:IGFBP4 [extracellular region] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-381487] IGFBP1 binds IGF forming IGF:IGFBP1 - Xenopus tropicalis [Reaction:R-XTR-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Xenopus tropicalis [Reaction:R-XTR-2404200] IGF1,2 binds IGF1R - Xenopus tropicalis [Reaction:R-XTR-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10671057
displayName	IGF1,2 [extracellular region]
hasMember	[EntityWithAccessionedSequence:R-XTR-2404178] igf1 [extracellular region] - Xenopus tropicalis [EntityWithAccessionedSequence:R-XTR-2404175] igf2 [extracellular region] - Xenopus tropicalis
inDisease	false
inferredFrom	[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-XTR-481033] Platelet alpha granule contents [extracellular region] - Xenopus tropicalis
name	IGF1,2 Insulin-like Growth Factor
producedByEvent	[Reaction:R-XTR-381518] PAAP-A proteolyzes IGF:IGFBP4 - Xenopus tropicalis
schemaClass	DefinedSet
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-381451

(input)	[Reaction:R-XTR-381412] IGFBP2 binds IGF forming IGF:IGFBP2 [Reaction:R-XTR-381487] IGFBP1 binds IGF forming IGF:IGFBP1 [Reaction:R-XTR-381543] IGFBP4 binds IGF forming IGF:IGFBP4 [Reaction:R-XTR-2404200] IGF1,2 binds IGF1R
(hasComponent)	[Complex:R-XTR-381473] IGF:IGFBP2 [extracellular region] [Complex:R-XTR-381539] IGF:IGFBP1 [extracellular region] [Complex:R-XTR-381509] IGF:IGFBP4 [extracellular region] [Complex:R-XTR-2404189] IGF1,2:p-3Y-IGF1R [plasma membrane] [Complex:R-XTR-2404186] IGF1,2:IGF1R [plasma membrane]
(output)	[Reaction:R-XTR-381518] PAAP-A proteolyzes IGF:IGFBP4
(hasMember)	[DefinedSet:R-XTR-481033] Platelet alpha granule contents [extracellular region]
(inferredTo)	[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region]