Reactome | Thrombin proteolyzes IGF:IGFBP3:ALS

Schema > Reaction > Entries

Thrombin proteolyzes IGF:IGFBP3:ALS Show undefined attributes

catalystActivity	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:381505] May, B, 2008-11-19 20:29:10
dbId	381446
displayName	Thrombin proteolyzes IGF:IGFBP3:ALS
edited	[InstanceEdit:381443] May, B, Gopinathrao, G, 2008-11-19 20:02:07
eventOf	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
input	[Complex:R-HSA-381536] IGF:IGFBP3:ALS [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:538701] IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis [LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins [LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms [LiteratureReference:381401] The role of insulin-like growth factor binding proteins [LiteratureReference:381502] Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Thrombin proteolyzes IGF:IGFBP3:ALS
orthologousEvent	[Reaction:R-DRE-381446] Thrombin proteolyzes IGF:IGFBP3:ALS - Danio rerio [Reaction:R-RNO-381446] Thrombin proteolyzes IGF:IGFBP3:ALS - Rattus norvegicus
output	[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region] [EntityWithAccessionedSequence:R-HSA-381498] IGFALS [extracellular region] [EntityWithAccessionedSequence:R-HSA-381465] IGFBP3(125-233) [extracellular region] [EntityWithAccessionedSequence:R-HSA-381546] IGFBP3(234-291) [extracellular region] [EntityWithAccessionedSequence:R-HSA-381547] IGFBP3(28-124) [extracellular region]
precedingEvent	[Reaction:R-HSA-381496] Formation of the IGF:IGFBP3:ALS complex - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-381446
summation	[Summation:381442] Thrombin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex betw...
updateTrackers	[UpdateTracker:9790657] Update Tracker - [Reaction:381446] Thrombin proteolyzes IGF:IGFBP3:ALS - v33:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790657] Update Tracker - [Reaction:381446] Thrombin proteolyzes IGF:IGFBP3:ALS - v33:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)