Reactome | PAPP-A2 proteolyzes IGF:IGFBP5:ALS

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PAPP-A2 proteolyzes IGF:IGFBP5:ALS Show undefined attributes

catalystActivity	[CatalystActivity:381438] metalloendopeptidase activity of PAPPA,PAPPA2 [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:381505] May, B, 2008-11-19 20:29:10
dbId	381537
displayName	PAPP-A2 proteolyzes IGF:IGFBP5:ALS
edited	[InstanceEdit:381443] May, B, Gopinathrao, G, 2008-11-19 20:02:07
eventOf	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
input	[Complex:R-HSA-381423] IGF:IGFBP5:ALS [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:381527] Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase [LiteratureReference:381486] Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A [LiteratureReference:381400] Cellular actions of the insulin-like growth factor binding proteins [LiteratureReference:381441] Molecular distribution of IGF binding protein-5 in human serum [LiteratureReference:381476] Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells [LiteratureReference:381407] IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms [LiteratureReference:381401] The role of insulin-like growth factor binding proteins
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	PAPP-A2 proteolyzes IGF:IGFBP5:ALS
orthologousEvent	[Reaction:R-DRE-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - Danio rerio [Reaction:R-RNO-381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - Rattus norvegicus
output	[DefinedSet:R-HSA-381451] IGF1,2 [extracellular region] [EntityWithAccessionedSequence:R-HSA-381498] IGFALS [extracellular region] [EntityWithAccessionedSequence:R-HSA-381478] IGFBP5(164-272) [extracellular region] [EntityWithAccessionedSequence:R-HSA-381415] IGFBP5(21-163) [extracellular region]
precedingEvent	[Reaction:R-HSA-381545] Formation of the IGF:IGFBP5:ALS complex - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-381537
summation	[Summation:381422] Both Pregnancy Associated Plasma Protein A (PAPP-A) and A2 (...
updateTrackers	[UpdateTracker:9790756] Update Tracker - [Reaction:381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - v33:[modifyText, removeLiteratureReference, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9790756] Update Tracker - [Reaction:381537] PAPP-A2 proteolyzes IGF:IGFBP5:ALS - v33:[modifyText, removeLiteratureReference, removeOutput]
(hasEvent)	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

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