Reactome | PKMTs methylate histone lysines

Schema > Pathway > Entries

PKMTs methylate histone lysines Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
created	[InstanceEdit:3214866] Jupe, S, 2013-03-12
dbId	3214841
displayName	PKMTs methylate histone lysines
doi	10.3180/REACT_268728.2
edited	[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
eventOf	[Pathway:R-HSA-3247509] Chromatin modifying enzymes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Homo sapiens [Reaction:R-HSA-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - Homo sapiens [Reaction:R-HSA-5244692] Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) - Homo sapiens [Reaction:R-HSA-5634750] EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) - Homo sapiens [Reaction:R-HSA-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Homo sapiens [Reaction:R-HSA-5634802] MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) - Homo sapiens [Reaction:R-HSA-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Homo sapiens [Reaction:R-HSA-5638332] PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) - Homo sapiens [Reaction:R-HSA-5638333] WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27) - Homo sapiens [Reaction:R-HSA-5649800] WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27) - Homo sapiens [Reaction:R-HSA-5649802] WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27) - Homo sapiens [Reaction:R-HSA-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Homo sapiens [Reaction:R-HSA-5638157] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36) - Homo sapiens [Reaction:R-HSA-5638141] SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36) - Homo sapiens [Reaction:R-HSA-5159250] ATF7IP binds SETDB1 - Homo sapiens [Reaction:R-HSA-5649801] DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79) - Homo sapiens [Reaction:R-HSA-5649764] DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79) - Homo sapiens [Reaction:R-HSA-5649799] DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79) - Homo sapiens [Reaction:R-HSA-5423038] SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) - Homo sapiens [Reaction:R-HSA-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Homo sapiens [Reaction:R-HSA-5651657] SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) - Homo sapiens [Reaction:R-HSA-8865237] SETD6 methylates RELA in the NFkB complex - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:3214829] Protein methyltransferases as a target class for drug discovery [LiteratureReference:3301870] Histone methylation in transcriptional control
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PKMTs methylate histone lysines
orthologousEvent	[Pathway:R-PFA-3214841] PKMTs methylate histone lysines - Plasmodium falciparum [Pathway:R-SPO-3214841] PKMTs methylate histone lysines - Schizosaccharomyces pombe [Pathway:R-CEL-3214841] PKMTs methylate histone lysines - Caenorhabditis elegans [Pathway:R-DME-3214841] PKMTs methylate histone lysines - Drosophila melanogaster [Pathway:R-GGA-3214841] PKMTs methylate histone lysines - Gallus gallus [Pathway:R-XTR-3214841] PKMTs methylate histone lysines - Xenopus tropicalis [Pathway:R-DRE-3214841] PKMTs methylate histone lysines - Danio rerio [Pathway:R-SSC-3214841] PKMTs methylate histone lysines - Sus scrofa [Pathway:R-BTA-3214841] PKMTs methylate histone lysines - Bos taurus [Pathway:R-CFA-3214841] PKMTs methylate histone lysines - Canis familiaris [Pathway:R-RNO-3214841] PKMTs methylate histone lysines - Rattus norvegicus [Pathway:R-MMU-3214841] PKMTs methylate histone lysines - Mus musculus
releaseDate	2015-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3214841
summation	[Summation:3214819] Lysine methyltransferases (KMTs) and arginine methyltransfer...
updateTrackers	[UpdateTracker:9784556] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v53:[updateContainedRLE] [UpdateTracker:9782867] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v58:[addHasEvent, updateContainedRLE] [UpdateTracker:9785156] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v52:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9782523] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v59:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9784556] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v53:[updateContainedRLE]
[UpdateTracker:9782867] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v58:[addHasEvent, updateContainedRLE]
[UpdateTracker:9785156] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v52:[add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9782523] Update Tracker - [Pathway:3214841] PKMTs methylate histone lysines - v59:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-3247509] Chromatin modifying enzymes

Cite Us!