Reactome | WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)

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WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:4827374] histone H3 methyltransferase activity of WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4827380] Jupe, S, 2013-10-29
dbId	4827383
displayName	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)
edited	[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
eventOf	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-HSA-4657030] Histone H3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3301907] The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate [LiteratureReference:5173306] NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [LiteratureReference:5638155] Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex [LiteratureReference:5638166] The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) WHSC1, NSD1, SMYD2 methylate lysine-37 of histone H3
orthologousEvent	[Reaction:R-PFA-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Plasmodium falciparum [Reaction:R-SCE-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Saccharomyces cerevisiae [Reaction:R-SPO-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Schizosaccharomyces pombe [Reaction:R-DDI-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Dictyostelium discoideum [Reaction:R-CEL-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Caenorhabditis elegans [Reaction:R-SSC-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Sus scrofa [Reaction:R-BTA-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Bos taurus [Reaction:R-CFA-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Canis familiaris [Reaction:R-RNO-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Rattus norvegicus [Reaction:R-MMU-4827383] WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36) - Mus musculus
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-HSA-5638139] MeK37-histone H3 [nucleoplasm]
releaseDate	2015-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4827383
summation	[Summation:4827377] Methylation of histone H3 lysine-37 (H3K36) is tightly assoc...
systematicName	WHSC1, NSD1, SMYD2 transfer CH3 from AdoMet to histone H3

Referrals

(hasEvent)

[Pathway:R-HSA-3214841] PKMTs methylate histone lysines