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Entries
EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)
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authored
[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity
[CatalystActivity:5634755] histone H3 methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5634718] Jupe, Steve, 2014-11-05
dbId
5634729
displayName
EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)
edited
[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
eventOf
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
input
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[CandidateSet:R-HSA-4827376] MeK10-histone H3 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3301891] G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
[LiteratureReference:427757] Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains
maxDepth
1
modified
[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name
EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)
EHMT1:EHMT2 (KMT1D:KMT1C) methylates MeK10-histone H3 (H3K9)
EHMT1:EHMT2 methylates MeK10-histone H3
orthologousEvent
[Reaction:R-DRE-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Danio rerio
[Reaction:R-SSC-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Sus scrofa
[Reaction:R-BTA-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Bos taurus
[Reaction:R-CFA-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Canis familiaris
[Reaction:R-RNO-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Rattus norvegicus
[Reaction:R-MMU-5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - Mus musculus
output
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[CandidateSet:R-HSA-5634724] Me2K10-histone H3 [nucleoplasm]
releaseDate
2015-03-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5634729
summation
[Summation:5634759] EHMT2 (KMT1C, G9A) and EHMT1 (KMT1D, GLP) are the euchromati...
systematicName
EHMT1:EHMT2:WIZ transfers CH3 from AdoMet to MeK10-replicative histone H3
updateTrackers
[UpdateTracker:9785476] Update Tracker - [Reaction:5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - v52:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9785476] Update Tracker - [Reaction:5634729] EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) - v52:[modifyText]
(hasEvent)
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines
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