Reactome | SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)

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SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:5159240] histone H3 methyltransferase activity of SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5159248] Jupe, S, 2013-11-22
dbId	5159245
displayName	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)
edited	[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
eventOf	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
followingEvent	[Reaction:R-HSA-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-HSA-4657030] Histone H3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3301884] Structure and catalytic mechanism of the human histone methyltransferase SET7/9 [LiteratureReference:5637676] Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity [LiteratureReference:5244751] Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus [LiteratureReference:5244753] Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases [LiteratureReference:4687068] PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex [LiteratureReference:5244703] Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 [LiteratureReference:5669136] MLL targets SET domain methyltransferase activity to Hox gene promoters [LiteratureReference:5688407] Histone methyltransferase SETD3 regulates muscle differentiation
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) SETD3, SETD7, WHSC1L1, Core MLL complex methylate lysine-5 of histone H3
orthologousEvent	[Reaction:R-PFA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Plasmodium falciparum [Reaction:R-SCE-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Saccharomyces cerevisiae [Reaction:R-SPO-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Schizosaccharomyces pombe [Reaction:R-DDI-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Dictyostelium discoideum [Reaction:R-CEL-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Caenorhabditis elegans [Reaction:R-SSC-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Sus scrofa [Reaction:R-BTA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Bos taurus [Reaction:R-CFA-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Canis familiaris [Reaction:R-RNO-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Rattus norvegicus [Reaction:R-MMU-5159245] SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) - Mus musculus
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-HSA-5173296] MeK5-histone H3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9675026] Formation of the MLL1 complex - Homo sapiens [Reaction:R-HSA-9676255] Formation of the MLL2 complex - Homo sapiens [Reaction:R-HSA-9676254] Formation of the MLL3 complex - Homo sapiens [Reaction:R-HSA-9676268] Formation of the MLL4 complex - Homo sapiens [Reaction:R-HSA-9676257] Formation of the SET1A complex - Homo sapiens [Reaction:R-HSA-9676264] Formation of the SET1B complex - Homo sapiens
releaseDate	2015-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5159245
summation	[Summation:5173299] Tri-methylation of lysine-5 of histone H3 (H3K4) has been li...
systematicName	SETD7, WHSC1L1, Core MLL complex transfer CH3 from AdoMet to Replicative histone H3

Referrals

(hasEvent)	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines
(precedingEvent)	[Reaction:R-HSA-5637686] WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)