Reactome | SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)

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SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) Show undefined attributes

authored	[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity	[CatalystActivity:4827381] histone H3 methyltransferase activity of SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4827380] Jupe, S, 2013-10-29
dbId	4827382
displayName	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)
edited	[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
eventOf	[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [CandidateSet:R-HSA-5634724] Me2K10-histone H3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3301877] Regulation of chromatin structure by site-specific histone H3 methyltransferases [LiteratureReference:427759] Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis [LiteratureReference:427757] Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains [LiteratureReference:5173305] SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate Me2K10-histone H3 (H3K9) SUV39H1, SUV39H2, SETDB1, SETDB2 methylate Me2K10-histone H3
orthologousEvent	[Reaction:R-SCE-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Saccharomyces cerevisiae [Reaction:R-SPO-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Schizosaccharomyces pombe [Reaction:R-DDI-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Dictyostelium discoideum [Reaction:R-CEL-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Caenorhabditis elegans [Reaction:R-SSC-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Sus scrofa [Reaction:R-BTA-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Bos taurus [Reaction:R-CFA-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Canis familiaris [Reaction:R-RNO-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Rattus norvegicus [Reaction:R-MMU-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Mus musculus
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [CandidateSet:R-HSA-5634754] Me3K10-histone H3 [nucleoplasm]
regulatedBy	[PositiveRegulation:R-HSA-5159251] Positive regulation by 'ATF7IP:SETDB1 [nucleoplasm]'
releaseDate	2015-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4827382
summation	[Summation:4827378] SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selec...
systematicName	SUV39H1, SUV39H2, SETDB1, SETDB2 transfer CH3 from AdoMet to Me2K10-replicative histone H3

Referrals

(hasEvent)

[Pathway:R-HSA-3214841] PKMTs methylate histone lysines

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