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Entries
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)
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authored
[InstanceEdit:3214866] Jupe, S, 2013-03-12
catalystActivity
[CatalystActivity:4827381] histone H3 methyltransferase activity of SUV39H1, SUV39H2, SETDB1, SETDB2 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:4827380] Jupe, S, 2013-10-29
dbId
4827382
displayName
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)
edited
[InstanceEdit:5622078] Jupe, Steve, 2014-09-10
eventOf
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines - Homo sapiens
input
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[CandidateSet:R-HSA-5634724] Me2K10-histone H3 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3301877] Regulation of chromatin structure by site-specific histone H3 methyltransferases
[LiteratureReference:427759] Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis
[LiteratureReference:427757] Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains
[LiteratureReference:5173305] SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate Me2K10-histone H3 (H3K9)
SUV39H1, SUV39H2, SETDB1, SETDB2 methylate Me2K10-histone H3
orthologousEvent
[Reaction:R-CEL-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Caenorhabditis elegans
[Reaction:R-DRE-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Danio rerio
[Reaction:R-SSC-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Sus scrofa
[Reaction:R-BTA-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Bos taurus
[Reaction:R-CFA-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Canis familiaris
[Reaction:R-RNO-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Rattus norvegicus
[Reaction:R-MMU-4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - Mus musculus
output
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[CandidateSet:R-HSA-5634754] Me3K10-histone H3 [nucleoplasm]
regulatedBy
[PositiveRegulation:R-HSA-5159251] Positive regulation by 'ATF7IP:SETDB1 [nucleoplasm]'
releaseDate
2015-03-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5643671] Motamedi, Mo, 2014-11-17
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-4827382
summation
[Summation:4827378] SUV39H1 (KMT1A) and SUV39H2 (KMT1B) and SETDB2 (KMT1F) selec...
systematicName
SUV39H1, SUV39H2, SETDB1, SETDB2 transfer CH3 from AdoMet to Me2K10-replicative histone H3
updateTrackers
[UpdateTracker:9784883] Update Tracker - [Reaction:4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - v52:[modifyText, removeLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9784883] Update Tracker - [Reaction:4827382] SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9) - v52:[modifyText, removeLiteratureReference]
(hasEvent)
[Pathway:R-HSA-3214841] PKMTs methylate histone lysines
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